ID   YMP3_STRCH              Reviewed;         251 AA.
AC   P43168;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Uncharacterized oxidoreductase in mprA 5'region;
DE            EC=1.-.-.-;
DE   AltName: Full=ORF3;
OS   Streptomyces coelicolor.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=1902;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 3030 / Mueller;
RX   PubMed=1406267; DOI=10.1111/j.1365-2958.1992.tb01402.x;
RA   Dammann T., Wohlleben W.;
RT   "A metalloprotease gene from Streptomyces coelicolor 'Muller' and its
RT   transcriptional activator, a member of the LysR family.";
RL   Mol. Microbiol. 6:2267-2278(1992).
CC   -!- FUNCTION: May be involved in the biosynthesis of a heptaene-type
CC       antibiotic.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; Z11929; CAA77984.1; -; Genomic_DNA.
DR   PIR; S25186; S25186.
DR   AlphaFoldDB; P43168; -.
DR   SMR; P43168; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Oxidoreductase.
FT   CHAIN           1..251
FT                   /note="Uncharacterized oxidoreductase in mprA 5'region"
FT                   /id="PRO_0000054890"
FT   ACT_SITE        158
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         14..37
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
FT   BINDING         145
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   251 AA;  25778 MW;  AF39BF3E53B58A01 CRC64;
     MPKDASGPPR SLLVLGGTSA IGLATARRLI ARGARLVHLA ARPSPALEKA AGELTALGAE
     VRTVPFDALD PESHQASLGP VFAAGDVDLV LLRFGIAGDQ ARDESRPLDA VRVAQTNYTG
     AVGAGLLCGA ALQEQGHGTL VVLSSAAGVR ARRADFIYGS SKAGLDAFAQ GLGDALYGTG
     VRVMVVRPGT VLDPGTPRGD ARLTTTPGQV AAAIELGLRR GSETVWVPGG LRLVMSAVRG
     LPRPLFRRLV V