ID   YMP5_STRCH              Reviewed;         278 AA.
AC   P43169;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Uncharacterized protein in mprR 3'region;
DE            EC=1.-.-.-;
DE   AltName: Full=ORF5;
DE   Flags: Fragment;
OS   Streptomyces coelicolor.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=1902;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 3030 / Mueller;
RX   PubMed=1406267; DOI=10.1111/j.1365-2958.1992.tb01402.x;
RA   Dammann T., Wohlleben W.;
RT   "A metalloprotease gene from Streptomyces coelicolor 'Muller' and its
RT   transcriptional activator, a member of the LysR family.";
RL   Mol. Microbiol. 6:2267-2278(1992).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000305}.
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DR   EMBL; Z11929; CAA77987.1; -; Genomic_DNA.
DR   PIR; S25189; S25189.
DR   AlphaFoldDB; P43169; -.
DR   SMR; P43169; -.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase.
FT   CHAIN           <1..278
FT                   /note="Uncharacterized protein in mprR 3'region"
FT                   /id="PRO_0000076035"
FT   ACT_SITE        193
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        222
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        241
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         112..113
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         191..193
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         217
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         241..244
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   278 AA;  28606 MW;  0994B1E7F7613ACF CRC64;
     ITGAEGGAPD APLVLVGAHP AARLRGDPRV RWFHSVNAGV DALLDGGWPA GVLLTRTVGR
     MGERIGQYAL AWVLADCQGV PGHLARTAAP PGAANPPNWP RGQTALVYGT GHIGTAVASR
     LGAAGLHTVG VGRAEHAPGG PFDERITAGE DGPWLGRARF VVDALPLTDA TRDFFADARL
     SALRGATFLN VGRGATVSLP ALGRALAAGH VRGAVLDVLT DEPPAPGHPV WELPRTTLTS
     HSAGITAGTD ITADFRACWE ALRAGQAPEL AVRVGRGY