ID   YMXG_HELPY              Reviewed;         432 AA.
AC   O25371;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Non-peptidase homolog YmxG {ECO:0000303|PubMed:33970782};
DE   Flags: Precursor;
GN   Name=ymxG {ECO:0000303|PubMed:33970782};
GN   OrderedLocusNames=HP_0657 {ECO:0000312|EMBL:AAD07722.1};
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
RN   [2]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 43504 / NCTC 11637 / JCM 7653 / RPH 13487, and
RC   ATCC 700392 / 26695;
RX   PubMed=17533641; DOI=10.1002/pmic.200600875;
RA   Smith T.G., Lim J.M., Weinberg M.V., Wells L., Hoover T.R.;
RT   "Direct analysis of the extracellular proteome from two strains of
RT   Helicobacter pylori.";
RL   Proteomics 7:2240-2245(2007).
RN   [3]
RP   FUNCTION.
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=33970782; DOI=10.1080/19490976.2021.1921928;
RA   Marques M.S., Costa A.C., Osorio H., Pinto M.L., Relvas S.,
RA   Dinis-Ribeiro M., Carneiro F., Leite M., Figueiredo C.;
RT   "Helicobacter pylori PqqE is a new virulence factor that cleaves junctional
RT   adhesion molecule A and disrupts gastric epithelial integrity.";
RL   Gut Microbes 13:1-21(2021).
CC   -!- FUNCTION: May contribute to the full activity of the protease PqqE.
CC       {ECO:0000269|PubMed:33970782}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17533641}.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family. {ECO:0000305}.
CC   -!- CAUTION: Does not seem to have protease activity as it lacks the
CC       conserved zinc-binding sites and the active site.
CC       {ECO:0000305|PubMed:33970782}.
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DR   EMBL; AE000511; AAD07722.1; -; Genomic_DNA.
DR   PIR; A64602; A64602.
DR   RefSeq; NP_207451.1; NC_000915.1.
DR   RefSeq; WP_000714010.1; NC_018939.1.
DR   AlphaFoldDB; O25371; -.
DR   SMR; O25371; -.
DR   IntAct; O25371; 3.
DR   MINT; O25371; -.
DR   STRING; 85962.C694_03395; -.
DR   PaxDb; O25371; -.
DR   EnsemblBacteria; AAD07722; AAD07722; HP_0657.
DR   KEGG; hpy:HP_0657; -.
DR   PATRIC; fig|85962.47.peg.707; -.
DR   eggNOG; COG0612; Bacteria.
DR   OMA; WAFPAPE; -.
DR   PhylomeDB; O25371; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 1.
DR   SUPFAM; SSF63411; SSF63411; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..432
FT                   /note="Non-peptidase homolog YmxG"
FT                   /id="PRO_5004157903"
SQ   SEQUENCE   432 AA;  48801 MW;  EDD161BD8E70AE79 CRC64;
     MKKFLITLLL GVFMGLQASA LTHQEINQAK VPVIYEENHL LPMGFIHLAF RGGGSLSDKN
     QLGLAKLFAQ VLNEGTKELG AVGFAQLLEQ KAISLNVDTS TEDLQITLEF LKEYEDEAIT
     RLKELLKSPN FTQNALEKVK TQMLAALLQK ESDFDYLAKL TLKQELFANT PLANAALGTK
     ESIQKIKLDD LKQQFAKVFE LNKLVVVLGG DLKIDQTLKR LNNALNFLPQ GKAYEEPYFE
     TSDKKSEKVL YKDTEQAFVY FGAPFKIKDL KQDLAKSKVM MFVLGGGFGS RLMEKIRVQE
     GLAYSVYIRS NFSKVAHFAS GYLQTKLSTQ TKSVALVKKI VKEFIEKGMT QQELDDAKKF
     LLGSEPLRNE TISSRLNTTY NYFYLGLPLN FNQTLLNQIQ KMSLKEINDF IKAHTEINDL
     TFAIVSNKKK DK