ID   YMZ2_YEAST              Reviewed;         834 AA.
AC   Q03177; D6VZS5; Q03138; Q04435;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 167.
DE   RecName: Full=WD repeat-containing protein YMR102C;
GN   OrderedLocusNames=YMR102C; ORFNames=YM6228.01C, YM6543.09C, YM9718.01C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-528, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17287358; DOI=10.1073/pnas.0607084104;
RA   Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,
RA   Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
RT   "Analysis of phosphorylation sites on proteins from Saccharomyces
RT   cerevisiae by electron transfer dissociation (ETD) mass spectrometry.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-771, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
CC   -!- MISCELLANEOUS: Present with 538 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the WD repeat DGR2 family. {ECO:0000305}.
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DR   EMBL; Z49702; CAA89738.1; -; Genomic_DNA.
DR   EMBL; Z50179; CAA90559.1; -; Genomic_DNA.
DR   EMBL; Z49807; CAA89903.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA09999.1; -; Genomic_DNA.
DR   PIR; S54563; S54563.
DR   RefSeq; NP_013820.1; NM_001182602.1.
DR   AlphaFoldDB; Q03177; -.
DR   BioGRID; 35278; 56.
DR   DIP; DIP-1963N; -.
DR   IntAct; Q03177; 6.
DR   MINT; Q03177; -.
DR   STRING; 4932.YMR102C; -.
DR   iPTMnet; Q03177; -.
DR   MaxQB; Q03177; -.
DR   PaxDb; Q03177; -.
DR   PRIDE; Q03177; -.
DR   EnsemblFungi; YMR102C_mRNA; YMR102C; YMR102C.
DR   GeneID; 855128; -.
DR   KEGG; sce:YMR102C; -.
DR   SGD; S000004708; YMR102C.
DR   VEuPathDB; FungiDB:YMR102C; -.
DR   eggNOG; KOG0283; Eukaryota.
DR   GeneTree; ENSGT00940000157557; -.
DR   HOGENOM; CLU_008245_0_0_1; -.
DR   InParanoid; Q03177; -.
DR   OMA; FHPNDDR; -.
DR   BioCyc; YEAST:G3O-32801-MON; -.
DR   PRO; PR:Q03177; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; Q03177; protein.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR040324; WDR44/Dgr2.
DR   PANTHER; PTHR14221; PTHR14221; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..834
FT                   /note="WD repeat-containing protein YMR102C"
FT                   /id="PRO_0000051481"
FT   REPEAT          171..210
FT                   /note="WD 1"
FT   REPEAT          276..314
FT                   /note="WD 2"
FT   REPEAT          316..356
FT                   /note="WD 3"
FT   REPEAT          358..398
FT                   /note="WD 4"
FT   REPEAT          423..468
FT                   /note="WD 5"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          761..789
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..227
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         528
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:17287358"
FT   MOD_RES         771
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:18407956"
SQ   SEQUENCE   834 AA;  94254 MW;  C7641BF91D9C38B4 CRC64;
     MTNMAEDKTS ISKVHSEFSN SSNTTGSEEE SRSHQESFDG ESSSGESKSK SKLNLEYSAD
     IEPLKFRMTK TNNTNDKLKY SNNGNATDSF MRLKEHLQRG NTLNSNLRVN EFYPFNSIDT
     EQFENYLREP KYIKMLKRRK NLKQFRRLFL AQELMAYEGE TVTSTSKSSE PTSKAIWSTK
     FSRDGKFMAT GSKDGKIRIW KVIGSPVERA ELDSSAESNK EARAKSMRIK QQVSSLNNPK
     EKQFLDSATE KYEEKEKLLN LYAPVFHPTP LRLYKEHVQD VLDINWSKNN FILSASMDKT
     VKLWHPDRKN SLKTFIHPDF VTCVEFHPTD DRFFISGCLD HKCRLWSILD DEVSFEYDCQ
     DLITSVTLSP EEGKYTIIGT FNGYVHILMT RGLTPVSSFH VADRQTQEQN AHVMVTETDS
     KIRHGPRVTG LQAFRSQLDN SFRLVVTSND SRIRIFDLEQ RKLLEVLKGF HSGSSQHKAQ
     LSIWHGQPIV VNSSDDHWVY GWRLKSSDRE NDQDEPKRKP KGLARSGSLR SIFSKSMSRS
     SSQNNEEKPH HHLKLTNLLP LPHHSNDHYI KNTDYISFHA HNAPVTCVSI APPETSKTLS
     LSNDVICELS LEFFQTSDSF DVLSRSNDDG IMSDVESSLG YNSKPGSISN ASATSAIPDV
     VDAIGTILIS TDNVGTIRVF RADMPSVIRK RVLLKLEEYN REVRRRFNSS DSLHSLSRSF
     NSRAKSNLAG QPAAAYTNTG KGYATGRGYS NICPKSSTSL KTLGSNAQPR TPRESMSSIF
     SNAHGPTTPT SAMNLPIRCN VCNGSRFEAF SGANDQQDRN YYCVDCGTVV NNFR