ID   CBP2_YEAST              Reviewed;         630 AA.
AC   P03874; D3DKT1;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 2.
DT   03-AUG-2022, entry version 164.
DE   RecName: Full=Cytochrome B pre-mRNA-processing protein 2;
GN   Name=CBP2; OrderedLocusNames=YHL038C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6348045; DOI=10.1016/s0021-9258(17)44690-4;
RA   McGraw P., Tzagoloff A.;
RT   "Assembly of the mitochondrial membrane system. Characterization of a yeast
RT   nuclear gene involved in the processing of the cytochrome b pre-mRNA.";
RL   J. Biol. Chem. 258:9459-9468(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8091229; DOI=10.1126/science.8091229;
RA   Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA   Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA   Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA   Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA   St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA   Waterston R., Wilson R., Vaudin M.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   VIII.";
RL   Science 265:2077-2082(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=9092668; DOI=10.1093/nar/25.8.1597;
RA   Shaw L.C., Lewin A.S.;
RT   "The Cbp2 protein stimulates the splicing of the omega intron of yeast
RT   mitochondria.";
RL   Nucleic Acids Res. 25:1597-1604(1997).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
CC   -!- FUNCTION: Appears to be specifically required for the splicing of the
CC       terminal intron (bI5) of the cytochrome b pre-mRNA. Can also stimulates
CC       the splicing of the omega intron of the precursor of large ribosomal
CC       RNA.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; K00138; AAA63570.1; -; Genomic_DNA.
DR   EMBL; U11583; AAB65050.1; -; Genomic_DNA.
DR   EMBL; BK006934; DAA06648.1; -; Genomic_DNA.
DR   PIR; S48930; BWBY.
DR   RefSeq; NP_011825.1; NM_001179118.1.
DR   AlphaFoldDB; P03874; -.
DR   BioGRID; 36385; 95.
DR   DIP; DIP-6581N; -.
DR   IntAct; P03874; 2.
DR   STRING; 4932.YHL038C; -.
DR   MaxQB; P03874; -.
DR   PaxDb; P03874; -.
DR   PRIDE; P03874; -.
DR   TopDownProteomics; P03874; -.
DR   EnsemblFungi; YHL038C_mRNA; YHL038C; YHL038C.
DR   GeneID; 856347; -.
DR   KEGG; sce:YHL038C; -.
DR   SGD; S000001030; CBP2.
DR   VEuPathDB; FungiDB:YHL038C; -.
DR   eggNOG; ENOG502RYC2; Eukaryota.
DR   HOGENOM; CLU_029563_0_0_1; -.
DR   InParanoid; P03874; -.
DR   OMA; SHKTLWS; -.
DR   BioCyc; YEAST:G3O-31056-MON; -.
DR   PRO; PR:P03874; -.
DR   Proteomes; UP000002311; Chromosome VIII.
DR   RNAct; P03874; protein.
DR   GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR   GO; GO:0003723; F:RNA binding; IDA:SGD.
DR   GO; GO:0000372; P:Group I intron splicing; IDA:SGD.
DR   GO; GO:0090615; P:mitochondrial mRNA processing; IMP:SGD.
DR   InterPro; IPR016424; Cbp2.
DR   PIRSF; PIRSF004611; CBP2; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; mRNA processing; mRNA splicing; Reference proteome.
FT   CHAIN           1..630
FT                   /note="Cytochrome B pre-mRNA-processing protein 2"
FT                   /id="PRO_0000089380"
FT   CONFLICT        490
FT                   /note="G -> S (in Ref. 1; AAA63570)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   630 AA;  73861 MW;  915413F4DD28827A CRC64;
     MVNWQTLFMV SLRRQGSSSR YRYKFNMENI THQVFPRCKQ AFKKTNLSYE YCDLEGVLYN
     ISLTDLQKLL LRDINAPREH AFKIVRTDLT QKSSKKRIQH WERIAPMFDH PLSLYEKLFS
     EMDEDFKPSF EWQQLIRVRC KDDKLKLQRV IWPKSIFSNF CRGIGVKKST YDRLLEQNNG
     EVPMFVNPAN AKPLPLFQVS DEAMIGEFDG IGIFPYFVDK HREFFVTEVD KLKTKIASPL
     CTLNERKRIE KANAGRILAN EEGKPFYLDA NSATTRIAGG NVVTLKQLLE RSVSHKTLWS
     KQSNKDRTCP GDILRATILS NDFSIRQLRA EFCKNFILYN IFTILQRNKK SIRSFSGNDN
     APSFQFSWNV WDSYIWKQYQ ETESMKIPTD QASLINYKTK YDSFLHDLQT YSALVISEMK
     WNQFSIFQND ETTLSRFEHI TLILQTVLTK SKMIRIFQPN LYKFMQDDLR PTLMELVGFT
     ESINATIEPG FANEQSLQSA NGLKKLANQL LYFEQEIYGE KFRVNRPIQL RPITLSANYK
     IVILDKKNAI PEIFQTLLKF MTQITTYFVK DLSEVELHGH MHCIDKKMLD KSKFMYLYEE
     KSNEEVKAAS PQKEKIVDNI IGLLSNDEEH