CBP3_YEAST
ID CBP3_YEAST Reviewed; 335 AA.
AC P21560; D6W3F5;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Protein CBP3, mitochondrial;
DE Flags: Precursor;
GN Name=CBP3; OrderedLocusNames=YPL215W; ORFNames=P1775;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2544586; DOI=10.1016/s0021-9258(18)60438-7;
RA Wu M., Tzagoloff A.;
RT "Identification and characterization of a new gene (CBP3) required for the
RT expression of yeast coenzyme QH2-cytochrome c reductase.";
RL J. Biol. Chem. 264:11122-11130(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP CHARACTERIZATION.
RX PubMed=11522252; DOI=10.1016/s0005-2728(01)00187-6;
RA Shi G., Crivellone M.D., Edderkaoui B.;
RT "Identification of functional regions of Cbp3p, an enzyme-specific
RT chaperone required for the assembly of ubiquinol-cytochrome c reductase in
RT yeast mitochondria.";
RL Biochim. Biophys. Acta 1506:103-116(2001).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Chaperone required for the assembly of ubiquinol-cytochrome c
CC reductase of the mitochondrial respiratory chain.
CC -!- INTERACTION:
CC P21560; P07253: CBP6; NbExp=4; IntAct=EBI-4134, EBI-4142;
CC P21560; P36517: MRPL4; NbExp=3; IntAct=EBI-4134, EBI-402;
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane.
CC -!- MISCELLANEOUS: Present with 14200 molecules/cell in log phase SD
CC medium. {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the CBP3 family. {ECO:0000305}.
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DR EMBL; J04830; AAA34475.1; -; Genomic_DNA.
DR EMBL; Z73571; CAA97930.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11221.1; -; Genomic_DNA.
DR PIR; A34290; A34290.
DR RefSeq; NP_015109.1; NM_001184029.1.
DR AlphaFoldDB; P21560; -.
DR SMR; P21560; -.
DR BioGRID; 35970; 73.
DR ComplexPortal; CPX-384; CBP3-CBP6 complex.
DR DIP; DIP-69N; -.
DR IntAct; P21560; 10.
DR MINT; P21560; -.
DR STRING; 4932.YPL215W; -.
DR MaxQB; P21560; -.
DR PaxDb; P21560; -.
DR PRIDE; P21560; -.
DR EnsemblFungi; YPL215W_mRNA; YPL215W; YPL215W.
DR GeneID; 855886; -.
DR KEGG; sce:YPL215W; -.
DR SGD; S000006136; CBP3.
DR VEuPathDB; FungiDB:YPL215W; -.
DR eggNOG; KOG2873; Eukaryota.
DR GeneTree; ENSGT00390000018118; -.
DR HOGENOM; CLU_051390_1_0_1; -.
DR InParanoid; P21560; -.
DR OMA; FSQWFQI; -.
DR BioCyc; YEAST:G3O-34104-MON; -.
DR PRO; PR:P21560; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; P21560; protein.
DR GO; GO:0061671; C:Cbp3p-Cbp6 complex; IPI:SGD.
DR GO; GO:0032592; C:integral component of mitochondrial membrane; IDA:SGD.
DR GO; GO:0005761; C:mitochondrial ribosome; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR GO; GO:0003729; F:mRNA binding; IDA:SGD.
DR GO; GO:0043022; F:ribosome binding; IDA:SGD.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; IDA:ComplexPortal.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; IMP:SGD.
DR GO; GO:0050821; P:protein stabilization; IDA:ComplexPortal.
DR InterPro; IPR021150; Ubiq_cyt_c_chap.
DR InterPro; IPR007129; Ubiqinol_cyt_c_chaperone_CPB3.
DR PANTHER; PTHR12184; PTHR12184; 1.
DR Pfam; PF03981; Ubiq_cyt_C_chap; 1.
PE 1: Evidence at protein level;
KW Chaperone; Membrane; Mitochondrion; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..38
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 39..335
FT /note="Protein CBP3, mitochondrial"
FT /id="PRO_0000004775"
FT TRANSMEM 152..169
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 335 AA; 39084 MW; 9384CBD3E083F6B9 CRC64;
MMSVNRFTSG RLPVFLRKSP FYYSRAYLHQ TCVFKQNKET AQDSPELLAK SSHLNSKPLD
VSNKAPVKTA QNKIPLAHSK YESSKYELPK WKEALGELVI RAFHLDMDRV RAGPVAGSYY
YKICKEQGLQ YEDEPLSETA KYFYEDLKLP RTFSQWFQIT VLHEWILFVR MRAMPFKYGR
NYQQKLVDRT FSDIELRLFE EMKVNSGRIA DQYLKDFNTQ LRGAIFAYDE GFATDDGTLA
TAVWRNLFGG RKNIDMVHLE SVVRYIYSQL YVLSRLSDRE FATGKFKFVP PGVKVEKLTP
KQEEELKAKT IAKYEALDKD PKTLPSERSR LSYTN
