ID   YN81_CAEEL              Reviewed;        1561 AA.
AC   Q03610;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 6.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Uncharacterized protein ZC84.1;
DE   Flags: Precursor;
GN   ORFNames=ZC84.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; Z19157; CAA79569.3; -; Genomic_DNA.
DR   PIR; E88550; E88550.
DR   PIR; S28291; S28291.
DR   RefSeq; NP_499036.3; NM_066635.3.
DR   AlphaFoldDB; Q03610; -.
DR   SMR; Q03610; -.
DR   STRING; 6239.ZC84.1; -.
DR   MEROPS; I02.955; -.
DR   EPD; Q03610; -.
DR   PaxDb; Q03610; -.
DR   PRIDE; Q03610; -.
DR   EnsemblMetazoa; ZC84.1.1; ZC84.1.1; WBGene00013846.
DR   GeneID; 191073; -.
DR   KEGG; cel:CELE_ZC84.1; -.
DR   UCSC; ZC84.1; c. elegans.
DR   CTD; 191073; -.
DR   WormBase; ZC84.1; CE43479; WBGene00013846; -.
DR   eggNOG; KOG4295; Eukaryota.
DR   HOGENOM; CLU_004071_0_0_1; -.
DR   InParanoid; Q03610; -.
DR   OMA; EKRCERS; -.
DR   OrthoDB; 25487at2759; -.
DR   PhylomeDB; Q03610; -.
DR   PRO; PR:Q03610; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00013846; Expressed in pharyngeal muscle cell (C elegans) and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00109; KU; 4.
DR   Gene3D; 4.10.410.10; -; 5.
DR   InterPro; IPR006150; Cys_repeat_1.
DR   InterPro; IPR006149; EB_dom.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR028150; Lustrin_cystein.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   Pfam; PF01683; EB; 3.
DR   Pfam; PF00014; Kunitz_BPTI; 5.
DR   Pfam; PF14625; Lustrin_cystein; 13.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 5.
DR   SMART; SM00289; WR1; 16.
DR   SUPFAM; SSF57362; SSF57362; 5.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 3.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 5.
PE   3: Inferred from homology;
KW   Disulfide bond; Protease inhibitor; Reference proteome; Repeat; Secreted;
KW   Serine protease inhibitor; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..1561
FT                   /note="Uncharacterized protein ZC84.1"
FT                   /id="PRO_0000155462"
FT   DOMAIN          309..363
FT                   /note="BPTI/Kunitz inhibitor 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DOMAIN          365..412
FT                   /note="WR1 1"
FT   DOMAIN          434..484
FT                   /note="BPTI/Kunitz inhibitor 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DOMAIN          487..525
FT                   /note="WR1 2"
FT   DOMAIN          531..581
FT                   /note="BPTI/Kunitz inhibitor 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DOMAIN          588..629
FT                   /note="WR1 3"
FT   DOMAIN          635..687
FT                   /note="BPTI/Kunitz inhibitor 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DOMAIN          690..737
FT                   /note="WR1 4"
FT   DOMAIN          743..795
FT                   /note="BPTI/Kunitz inhibitor 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DOMAIN          798..845
FT                   /note="WR1 5"
FT   DOMAIN          850..897
FT                   /note="WR1 6"
FT   DOMAIN          902..950
FT                   /note="WR1 7"
FT   DOMAIN          953..1000
FT                   /note="WR1 8"
FT   DOMAIN          1012..1059
FT                   /note="WR1 9"
FT   DOMAIN          1071..1115
FT                   /note="WR1 10"
FT   DOMAIN          1118..1162
FT                   /note="WR1 11"
FT   DOMAIN          1177..1209
FT                   /note="WR1 12"
FT   DOMAIN          1223..1266
FT                   /note="WR1 13"
FT   DOMAIN          1295..1342
FT                   /note="WR1 14"
FT   DOMAIN          1376..1416
FT                   /note="WR1 15"
FT   DOMAIN          1443..1488
FT                   /note="WR1 16"
FT   DISULFID        309..363
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        333..359
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        459..480
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        531..581
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        540..564
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        556..577
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        635..687
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        645..670
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        662..683
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        743..795
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        753..778
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        770..791
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
SQ   SEQUENCE   1561 AA;  169365 MW;  40DAE9CA28D00AE7 CRC64;
     MMFHSLGLLY LFLYVTLAED CIDRPCVECR HYIKQDDPCL HHGTKPMLFC DPQTNLIQES
     STNFLECVQN RWVLRECVTG TIYESGRGCV DPTIQPFMQG FSVSGSGRVG DVCQYNTDCL
     SGMYCATGLC SCLSTYILRE SYCYEKVNPN QPGCTYDVQC EAVWPGSKCR MDSSIGTCRC
     PEETHVARET RDGWVCISLR DLSSGGTAPL YFVCALPEGA GFKISLNDPS PSMGAFPVGC
     TVGSSATIEP VQGLHGGGAC MWPSDGEYIG DVYDCIHTSP HINLAEKFPQ SNYAPTADGV
     CCPSRALACI QPQLTGPNPS EPRWWYNSVT GTCQQFMWDS GATEAKYHSP NNFKTIQHCE
     SYCRDTCQRG SPQYSTESAV HSERPITSCA ASVSCANDFQ CTAIGSQHLC CPTPGSVCSA
     KGGRPYDIQP RTSIHHPGFM VYTGKESIRF YYDPGTGRCQ DFVYKGAGGN YNNFLSKHEC
     EMYCARLQCE RGSPLRIGEE AQRCQNNAQC PSSHECKADQ GVCCPRKQTI CAQPLRIGDC
     TENVKRYWYN ARTRQCQMFE YTGCQGNDNN FDSIMDCQNF CKNAIPEPKC IQGQAYKDMF
     GNFVTCSNGM GCPANYECYF DGSQWGCCPT KAFTCSLNTD SGIQCGAGST FKYYYNPQTQ
     NCESFQYNGC DGNSNNFANR DACESYCSVG GCPNGGTPLR DHSGMVMVCG AQQTSCPDSH
     ECIPVLVGNS LINRCCPTRA YMCGLPPQQG TQCGANYVQR YYFNIVTSQC TSFQFGGCDG
     NANNFLNIQQ CRNFCMSNAC PAGNVAYVDP NSQMPINCNE ALSNSCPSGY ACTFNPLINN
     HVCCGATDSG VCPEAEKAFI DTIDMSPREC LINIEQSCPA NYLCRFNMQK NKYYCCSSIT
     GKTCPVGKFL YKDLRTSQPI RCTIGRNDQC PDGFTCQSYL ANAFQGFCCT ANSVCPDNAD
     YLIDDQSQQP RACTQGTFVS CPNGYACRSL TSSADGFCCK SGTGALPPSV TDGCPPNEYV
     YLVQGEIAQC DPFNPPNAPC PSEFTCQWSL SNQRYQCCGS NPAPTPQRPS DGCPNAQIAF
     RDADAVRVCS AGAANCPAGY FCQFSSSNNQ FQCCGVSGGC PEESVAFVGM SGEPEKCVVG
     QSNCPRGFAC QKSLAGHHVC CTVRKVACES NEVIIEGECH AQVGPGSECL ANEQCTGGSV
     CEDAKCECRP PLKAVGGFCQ EEIQCSSNQV LHNGLCHNKA KLGEACLTVR QCQENSGCIE
     GSCECKKGFI EKAGKCMTPV EKKSAVSSKS INNGVTCSKP GWNPLIDEEH ERPKHCSPIG
     KACPNGYECQ INNRRTQYLC CAPDMSMSST VSIPSLPPPS TTTTERIMTT KKANLKVCPT
     GRTPYLLNGA PQKCTISRCP AGYECTYRNN GYHCCSMANK PGLTVAGTTG SVVSKSTPSP
     DQEKCPRGNP LIYPSTSSPV LCQPGKRGCP VGFGCVQSST SNNHICCPSR HSDRPGYQSE
     SFGLGAYYSR GPPAAINPCE GYLVLVTRGV NGRIEKRCER SCPFPQIPIG GVCYELKNKA
     T