YN9A_YEAST
ID YN9A_YEAST Reviewed; 342 AA.
AC P53757; D6W1P6;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Uncharacterized isomerase YNR071C;
DE EC=5.-.-.-;
GN OrderedLocusNames=YNR071C; ORFNames=N3605;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
CC -!- SIMILARITY: Belongs to the aldose epimerase family. {ECO:0000305}.
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DR EMBL; Z71686; CAA96353.1; -; Genomic_DNA.
DR EMBL; AY558019; AAS56345.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10612.1; -; Genomic_DNA.
DR PIR; S63404; S63404.
DR RefSeq; NP_014469.1; NM_001183248.1.
DR PDB; 1YGA; X-ray; 2.00 A; A/B=1-342.
DR PDBsum; 1YGA; -.
DR AlphaFoldDB; P53757; -.
DR SMR; P53757; -.
DR BioGRID; 35897; 71.
DR DIP; DIP-4561N; -.
DR IntAct; P53757; 3.
DR MINT; P53757; -.
DR STRING; 4932.YNR071C; -.
DR PaxDb; P53757; -.
DR EnsemblFungi; YNR071C_mRNA; YNR071C; YNR071C.
DR GeneID; 855808; -.
DR KEGG; sce:YNR071C; -.
DR SGD; S000005354; YNR071C.
DR VEuPathDB; FungiDB:YNR071C; -.
DR eggNOG; KOG1604; Eukaryota.
DR GeneTree; ENSGT00510000047589; -.
DR HOGENOM; CLU_031753_3_0_1; -.
DR InParanoid; P53757; -.
DR OMA; ATWLSCK; -.
DR BioCyc; YEAST:G3O-33375-MON; -.
DR EvolutionaryTrace; P53757; -.
DR PRO; PR:P53757; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P53757; protein.
DR GO; GO:0004034; F:aldose 1-epimerase activity; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0033499; P:galactose catabolic process via UDP-galactose; IBA:GO_Central.
DR GO; GO:0006006; P:glucose metabolic process; IBA:GO_Central.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR018052; Ald1_epimerase_CS.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR014718; GH-type_carb-bd.
DR Pfam; PF01263; Aldose_epim; 1.
DR SUPFAM; SSF74650; SSF74650; 1.
DR PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Carbohydrate metabolism; Isomerase; Reference proteome.
FT CHAIN 1..342
FT /note="Uncharacterized isomerase YNR071C"
FT /id="PRO_0000197449"
FT ACT_SITE 176
FT /note="Proton donor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10126"
FT BINDING 69
FT /ligand="substrate"
FT /evidence="ECO:0000255"
FT BINDING 240
FT /ligand="substrate"
FT /evidence="ECO:0000255"
FT STRAND 13..17
FT /evidence="ECO:0007829|PDB:1YGA"
FT TURN 18..20
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 21..26
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 31..37
FT /evidence="ECO:0007829|PDB:1YGA"
FT HELIX 49..52
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 68..70
FT /evidence="ECO:0007829|PDB:1YGA"
FT HELIX 71..73
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 74..77
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 80..83
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 91..93
FT /evidence="ECO:0007829|PDB:1YGA"
FT HELIX 96..98
FT /evidence="ECO:0007829|PDB:1YGA"
FT HELIX 100..102
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 111..114
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 117..126
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 128..132
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 136..149
FT /evidence="ECO:0007829|PDB:1YGA"
FT TURN 150..153
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 154..170
FT /evidence="ECO:0007829|PDB:1YGA"
FT TURN 181..185
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 193..198
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 201..205
FT /evidence="ECO:0007829|PDB:1YGA"
FT TURN 207..209
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 212..218
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 230..232
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 240..244
FT /evidence="ECO:0007829|PDB:1YGA"
FT TURN 246..250
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 253..255
FT /evidence="ECO:0007829|PDB:1YGA"
FT TURN 257..259
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 263..269
FT /evidence="ECO:0007829|PDB:1YGA"
FT TURN 271..273
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 276..289
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 304..310
FT /evidence="ECO:0007829|PDB:1YGA"
FT HELIX 314..316
FT /evidence="ECO:0007829|PDB:1YGA"
FT HELIX 318..321
FT /evidence="ECO:0007829|PDB:1YGA"
FT HELIX 322..324
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 325..327
FT /evidence="ECO:0007829|PDB:1YGA"
FT STRAND 332..341
FT /evidence="ECO:0007829|PDB:1YGA"
SQ SEQUENCE 342 AA; 37852 MW; 5FEBD290A892D6C9 CRC64;
MSNSNGDNKY GVITIGDEKK FQATIAPLGA TLVDLKVNGQ SVVQGYSNVQ DYLTDGNMMG
ATVGRYANRI AKGVFSLDDG PHKLTVNNCG NTNHSSISSL NLKQYKASPV ENPSKGVYVV
EFKLLDDHTQ PNPNEFPGDL EVTVKYTLNV AEMTLDMEYQ AQLVRGDATP INMTNHSYFN
LNKVKSEKSI RGTEVKVCSN KSLEVTEGAL LPTGKIIERN IATFDSTKPT VLHEDTPVFD
CTFIIDANKD LKTTDSVSVN KLVPVFKAYH PESHIKFEVS TTEPTVHLYT GDNLCGKFVP
RSGFAVQQGR YVDAINRDEW RGCVLLKRGE VYTSKTQYKF DI
