YNEA_BACSU
ID YNEA_BACSU Reviewed; 105 AA.
AC Q45056; Q796H0;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Cell division suppressor protein YneA;
GN Name=yneA; OrderedLocusNames=BSU17860;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8969507; DOI=10.1099/13500872-142-11-3097;
RA Rose M., Entian K.-D.;
RT "New genes in the 170 degrees region of the Bacillus subtilis genome encode
RT DNA gyrase subunits, a thioredoxin, a xylanase and an amino acid
RT transporter.";
RL Microbiology 142:3097-3101(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION AS SUPPRESSOR OF CELL DIVISION, AND INDUCTION.
RC STRAIN=168;
RX PubMed=12581363; DOI=10.1046/j.1365-2958.2003.03360.x;
RA Kawai Y., Moriya S., Ogasawara N.;
RT "Identification of a protein, YneA, responsible for cell division
RT suppression during the SOS response in Bacillus subtilis.";
RL Mol. Microbiol. 47:1113-1122(2003).
RN [4]
RP FUNCTION AS SUPPRESSOR OF CELL DIVISION.
RC STRAIN=168;
RX PubMed=16549676; DOI=10.1099/mic.0.28497-0;
RA Kawai Y., Ogasawara N.;
RT "Bacillus subtilis EzrA and FtsL synergistically regulate FtsZ ring
RT dynamics during cell division.";
RL Microbiology 152:1129-1141(2006).
CC -!- FUNCTION: Inhibits cell division during the SOS response. Affects a
CC later stage of the cell division protein assembly, after the assembly
CC of the Z ring, by probably suppressing recruitment of FtsL and/or DivIC
CC to the division machinery (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:12581363, ECO:0000269|PubMed:16549676}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- INDUCTION: Repressed by LexA. {ECO:0000269|PubMed:12581363}.
CC -!- SIMILARITY: Belongs to the YneA family. {ECO:0000305}.
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DR EMBL; Z73234; CAA97614.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13670.1; -; Genomic_DNA.
DR PIR; F69890; F69890.
DR RefSeq; NP_389669.1; NC_000964.3.
DR RefSeq; WP_003231598.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; Q45056; -.
DR SMR; Q45056; -.
DR STRING; 224308.BSU17860; -.
DR PaxDb; Q45056; -.
DR PRIDE; Q45056; -.
DR EnsemblBacteria; CAB13670; CAB13670; BSU_17860.
DR GeneID; 936112; -.
DR KEGG; bsu:BSU17860; -.
DR PATRIC; fig|224308.43.peg.1892; -.
DR eggNOG; COG1388; Bacteria.
DR OMA; FIEWVAD; -.
DR BioCyc; BSUB:BSU17860-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0051782; P:negative regulation of cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd00118; LysM; 1.
DR Gene3D; 3.10.350.10; -; 1.
DR HAMAP; MF_02014; YneA; 1.
DR InterPro; IPR022887; Cell_div_suppressor_YneA.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR Pfam; PF01476; LysM; 1.
DR SMART; SM00257; LysM; 1.
DR SUPFAM; SSF54106; SSF54106; 1.
DR PROSITE; PS51782; LYSM; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cytoplasm; DNA damage; DNA repair;
KW Reference proteome; Septation; SOS response.
FT CHAIN 1..105
FT /note="Cell division suppressor protein YneA"
FT /id="PRO_0000346641"
FT DOMAIN 38..89
FT /note="LysM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
SQ SEQUENCE 105 AA; 11888 MW; 3F623203FDCC8723 CRC64;
MIMSKESIIF VGLFTVILSA VILMLSYTSS GQELNQYVKI EVQQGDTLWS IADQVADTKK
INKNDFIEWV ADKNQLQTSD IQPGDELVIP LKKKHQDAYE LATVR
