ID   YNEE_ECO57              Reviewed;         304 AA.
AC   Q8XAZ3;
DT   21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=UPF0187 protein YneE;
GN   Name=yneE; OrderedLocusNames=Z2185, ECs2127;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0187 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG56246.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB35550.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG56246.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB35550.1; ALT_INIT; Genomic_DNA.
DR   PIR; B85723; B85723.
DR   PIR; G90894; G90894.
DR   RefSeq; NP_310154.2; NC_002695.1.
DR   RefSeq; WP_001302151.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8XAZ3; -.
DR   SMR; Q8XAZ3; -.
DR   STRING; 155864.EDL933_2118; -.
DR   EnsemblBacteria; AAG56246; AAG56246; Z2185.
DR   EnsemblBacteria; BAB35550; BAB35550; ECs_2127.
DR   GeneID; 917350; -.
DR   KEGG; ece:Z2185; -.
DR   KEGG; ecs:ECs_2127; -.
DR   PATRIC; fig|386585.9.peg.2233; -.
DR   eggNOG; COG3781; Bacteria.
DR   HOGENOM; CLU_029790_4_2_6; -.
DR   OMA; TDICGAC; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:InterPro.
DR   InterPro; IPR021134; Bestrophin/UPF0187.
DR   InterPro; IPR044669; UPF0187.
DR   PANTHER; PTHR33281; PTHR33281; 1.
DR   Pfam; PF01062; Bestrophin; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..304
FT                   /note="UPF0187 protein YneE"
FT                   /id="PRO_0000217664"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   304 AA;  34823 MW;  7168FAE1D576DE6C CRC64;
     MIVRPQQHWL RRIFVWHGSV LSKISSRLLL NFLFSIAVIF MLPWYTHLGI KFTLAPFSIL
     GVAIAIFLGF RNNAGYARYV EARKLWGQLM IASRSLLREV KTTLPDSASV REFARLQIAF
     AHCLRMTLRK QPQVEVLAHY LKTEDLQRVL ASNSPANRIL LIMGEWLAVQ RRNGQLSDIL
     FISLNDRLND ISAVLAGCER IAYTPIPFAY TLILHRTVYL FCIMLPFALV VDLHYMTPFI
     SVLISYTFIS LDCLAEELED PFGTENNDLP LDAICNAIEI DLLQMNDEAE IPAKVLPDRH
     YQLT