ID   YNF8_KLULA              Reviewed;         359 AA.
AC   Q6CLF2;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Vacuolar membrane protein KLLA0F03465g;
GN   OrderedLocusNames=KLLA0F03465g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PRM5 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG97945.1; -; Genomic_DNA.
DR   RefSeq; XP_455237.1; XM_455237.1.
DR   AlphaFoldDB; Q6CLF2; -.
DR   STRING; 28985.XP_455237.1; -.
DR   EnsemblFungi; CAG97945; CAG97945; KLLA0_F03465g.
DR   GeneID; 2895258; -.
DR   KEGG; kla:KLLA0_F03465g; -.
DR   eggNOG; ENOG502S625; Eukaryota.
DR   HOGENOM; CLU_061224_0_0_1; -.
DR   InParanoid; Q6CLF2; -.
DR   OMA; KINSMEG; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix; Vacuole.
FT   CHAIN           1..359
FT                   /note="Vacuolar membrane protein KLLA0F03465g"
FT                   /id="PRO_0000409317"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          19..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..311
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   359 AA;  38950 MW;  88998CB5A1A86368 CRC64;
     MDLEYYEASA VVLEERALPA LTTSTEETTA KQTSTNTDDD KTTSTSTSTS TGTSSKNTKL
     PSLTTKTTDG STLTTSTGTS STETASYTTP VMELPSAKGN PNIWSSNKPT GTVFIAVGSA
     AGFIFLALLV WFIINTWMSY SQAKQLKKFN NMEKQFQNPF IDDIDFSSGG GYYKADEDIS
     TYKDTPVPTK NGGNNSFTPY KRASHSMIRL LGGSTDDGFG GGTPSSIGNT NLGSMNPLER
     VDAIDAANTG VRKSLYISPT MEVMNQQRRS TLFNNLNQSA VSIDTPEMME PTRTVSPERR
     TYKHEKSKSS LSKLVDSTID LTASTTLDNQ KRQGRSKGHN KSSSITPSVY LDNMLEDNS