CBP4_MOROL
ID CBP4_MOROL Reviewed; 40 AA.
AC C0HKC7;
DT 15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=Chitin-binding protein 4 {ECO:0000303|Ref.1};
DE Short=Mo-CBP4 {ECO:0000303|PubMed:21675945};
DE Contains:
DE RecName: Full=Chitin-binding protein 4 chain A {ECO:0000303|Ref.1};
DE Contains:
DE RecName: Full=Chitin-binding protein 4 chain B {ECO:0000303|Ref.1};
DE Flags: Fragments;
OS Moringa oleifera (Horseradish tree) (Moringa pterygosperma).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Moringaceae; Moringa.
OX NCBI_TaxID=3735 {ECO:0000303|Ref.1};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC TISSUE=Seed {ECO:0000303|Ref.1};
RA Pereira M.S., Oliveira J.T.A., Vasconcelos I.M.;
RT "Anti-inflammatory and anti-hypernociceptive effects of oral administration
RT of Mo-CBP4, a chitin-binding protein from Moringa oleifera seeds.";
RL Submitted (JAN-2017) to UniProtKB.
RN [2] {ECO:0000305}
RP FUNCTION, AND GLYCOSYLATION.
RC TISSUE=Seed {ECO:0000303|PubMed:21675945};
RX PubMed=21675945; DOI=10.2174/092986611797200959;
RA Pereira M.L., de Oliveira H.D., de Oliveira J.T.A., Gifoni J.M.,
RA de Oliviera Rocha R., de Oliveira Bezerra de Sousa D., Vasconcelos I.M.;
RT "Purification of a chitin-binding protein from Moringa oleifera seeds with
RT potential to relieve pain and inflammation.";
RL Protein Pept. Lett. 18:1078-1085(2011).
RN [3]
RP FUNCTION.
RX PubMed=28634471; DOI=10.3389/fmicb.2017.00980;
RA Neto J.X.S., Pereira M.L., Oliveira J.T.A., Rocha-Bezerra L.C.B.,
RA Lopes T.D.P., Costa H.P.S., Sousa D.O.B., Rocha B.A.M., Grangeiro T.B.,
RA Freire J.E.C., Monteiro-Moreira A.C.O., Lobo M.D.P., Brilhante R.S.N.,
RA Vasconcelos I.M.;
RT "A Chitin-binding Protein Purified from Moringa oleifera Seeds Presents
RT Anticandidal Activity by Increasing Cell Membrane Permeability and Reactive
RT Oxygen Species Production.";
RL Front. Microbiol. 8:980-980(2017).
CC -!- FUNCTION: Chitin-binding protein (PubMed:21675945). Has antifungal
CC activity against C.krusei, C.albicans, C.tropicalis and C.parapsilosis
CC (PubMed:28634471). Has antinociceptive and anti-inflammatory activity
CC in mice (PubMed:21675945). {ECO:0000269|PubMed:21675945,
CC ECO:0000269|PubMed:28634471}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:21675945}.
CC -!- MASS SPECTROMETRY: Mass=3888.7; Method=Electrospray; Note=Chain A. The
CC measured range is 1-?.; Evidence={ECO:0000269|Ref.1};
CC -!- MASS SPECTROMETRY: Mass=8428.0; Method=Electrospray; Note=Chain B. The
CC measured range is 20-?.; Evidence={ECO:0000269|Ref.1};
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DR AlphaFoldDB; C0HKC7; -.
DR GO; GO:0008061; F:chitin binding; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Chitin-binding; Direct protein sequencing; Glycoprotein.
FT CHAIN 1..19
FT /note="Chitin-binding protein 4 chain A"
FT /evidence="ECO:0000269|Ref.1"
FT /id="PRO_0000439207"
FT CHAIN 20..40
FT /note="Chitin-binding protein 4 chain B"
FT /evidence="ECO:0000269|Ref.1"
FT /id="PRO_0000439208"
FT NON_CONS 19..20
FT /evidence="ECO:0000305"
FT NON_TER 40
FT /evidence="ECO:0000303|Ref.1"
SQ SEQUENCE 40 AA; 4892 MW; 05F20704A24F87A0 CRC64;
QQQQCRQGQQ THQRQRVCQA RRPAIQRCCQ QLRNIQVQCR
