YNFH_ECOLI
ID YNFH_ECOLI Reviewed; 284 AA.
AC P76173; P77142;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Anaerobic dimethyl sulfoxide reductase chain YnfH;
DE AltName: Full=DMSO reductase anchor subunit YnfH;
GN Name=ynfH; OrderedLocusNames=b1590, JW5261;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP DISRUPTION PHENOTYPE.
RC STRAIN=K12 / BW25113;
RX PubMed=25316676; DOI=10.1093/bioinformatics/btu671;
RA Vlasblom J., Zuberi K., Rodriguez H., Arnold R., Gagarinova A., Deineko V.,
RA Kumar A., Leung E., Rizzolo K., Samanfar B., Chang L., Phanse S.,
RA Golshani A., Greenblatt J.F., Houry W.A., Emili A., Morris Q., Bader G.,
RA Babu M.;
RT "Novel function discovery with GeneMANIA: a new integrated resource for
RT gene function prediction in Escherichia coli.";
RL Bioinformatics 31:306-310(2015).
CC -!- FUNCTION: Terminal reductase during anaerobic growth on various
CC sulfoxide and N-oxide compounds. The C subunit anchors the other two
CC subunits to the membrane and stabilize the catalytic subunits (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex consists of three subunits: YnfF, the reductase;
CC YnfG, an electron transfer protein, and YnfH, a membrane anchor
CC protein. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Cells grow to slightly higher density than wild-
CC type in sublethal levels of streptomycin (PubMed:25316676).
CC {ECO:0000269|PubMed:25316676}.
CC -!- SIMILARITY: Belongs to the DmsC family. {ECO:0000305}.
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DR EMBL; U00096; AAC74662.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15314.2; -; Genomic_DNA.
DR PIR; H64914; H64914.
DR RefSeq; NP_416107.1; NC_000913.3.
DR RefSeq; WP_000526503.1; NZ_SSZK01000001.1.
DR AlphaFoldDB; P76173; -.
DR SMR; P76173; -.
DR BioGRID; 4263479; 7.
DR ComplexPortal; CPX-6019; Putative dimethyl sulfoxide reductase.
DR STRING; 511145.b1590; -.
DR TCDB; 5.A.3.3.1; the prokaryotic molybdopterin-containing oxidoreductase (pmo) family.
DR jPOST; P76173; -.
DR PaxDb; P76173; -.
DR PRIDE; P76173; -.
DR EnsemblBacteria; AAC74662; AAC74662; b1590.
DR EnsemblBacteria; BAA15314; BAA15314; BAA15314.
DR GeneID; 945822; -.
DR KEGG; ecj:JW5261; -.
DR KEGG; eco:b1590; -.
DR PATRIC; fig|1411691.4.peg.672; -.
DR EchoBASE; EB3607; -.
DR eggNOG; COG3302; Bacteria.
DR HOGENOM; CLU_064909_2_0_6; -.
DR OMA; MMSNEIA; -.
DR PhylomeDB; P76173; -.
DR BioCyc; EcoCyc:G6848-MON; -.
DR BioCyc; MetaCyc:G6848-MON; -.
DR PRO; PR:P76173; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0009390; C:dimethyl sulfoxide reductase complex; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:1990204; C:oxidoreductase complex; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0009389; F:dimethyl sulfoxide reductase activity; IBA:GO_Central.
DR GO; GO:0019645; P:anaerobic electron transport chain; IEA:InterPro.
DR GO; GO:0009061; P:anaerobic respiration; IBA:GO_Central.
DR InterPro; IPR007059; DmsC.
DR PANTHER; PTHR38095; PTHR38095; 1.
DR Pfam; PF04976; DmsC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Oxidoreductase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..284
FT /note="Anaerobic dimethyl sulfoxide reductase chain YnfH"
FT /id="PRO_0000168967"
FT TOPO_DOM 1..9
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..86
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..115
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..148
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..180
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..222
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..284
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 284 AA; 30524 MW; 73F7D760FC4B1344 CRC64;
MGNGWHEWPL VIFTVLGQCV VGALIVSGIG WFAAKNDADR QRIVRGMFFL WLLMGVGFIA
SVMHLGSPLR AFNSLNRIGA SGLSNEIAAG SIFFAVGGLW WLVAVIGKMP QALGKLWLLF
SMALGVIFVW MMTCVYQIDT VPTWHNGYTT LAFFLTVLLS GPILAAAILR AARVTFNTTP
FAIISVLALI ACAGVIVLQG LSLASIHSSV QQASALVPDY ASLQVWRVVL LCAGLGCWLC
PLIRRREPHV AGLILGLILI LGGEMIGRVL FYGLHMTVGM AIAG
