ID   YNFL_ECOLI              Reviewed;         297 AA.
AC   P77559;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator YnfL;
GN   Name=ynfL; OrderedLocusNames=b1595, JW1587;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA   Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA   Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA   Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA   Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA   Wada C., Yamamoto Y., Horiuchi T.;
RT   "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 28.0-40.1 min region on the linkage map.";
RL   DNA Res. 3:363-377(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; U00096; AAC74667.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15319.1; -; Genomic_DNA.
DR   PIR; E64915; E64915.
DR   RefSeq; NP_416112.1; NC_000913.3.
DR   RefSeq; WP_001019525.1; NZ_SSZK01000001.1.
DR   AlphaFoldDB; P77559; -.
DR   SMR; P77559; -.
DR   BioGRID; 4259120; 11.
DR   DIP; DIP-12771N; -.
DR   IntAct; P77559; 1.
DR   STRING; 511145.b1595; -.
DR   jPOST; P77559; -.
DR   PaxDb; P77559; -.
DR   PRIDE; P77559; -.
DR   EnsemblBacteria; AAC74667; AAC74667; b1595.
DR   EnsemblBacteria; BAA15319; BAA15319; BAA15319.
DR   GeneID; 946136; -.
DR   KEGG; ecj:JW1587; -.
DR   KEGG; eco:b1595; -.
DR   PATRIC; fig|1411691.4.peg.667; -.
DR   EchoBASE; EB3611; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_4_6; -.
DR   InParanoid; P77559; -.
DR   OMA; GKQPELC; -.
DR   PhylomeDB; P77559; -.
DR   BioCyc; EcoCyc:G6853-MON; -.
DR   PRO; PR:P77559; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..297
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   YnfL"
FT                   /id="PRO_0000105809"
FT   DOMAIN          1..60
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        20..40
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   297 AA;  33281 MW;  7D110818B677EF3D CRC64;
     MNIELRHLRY FVAVAEELHF GRAAARLNIS QPPLSQQIQA LEQQIGARLL ARTNRSVLLT
     AAGKQFLADS RQILSMVDDA AARAERLHQG EAGELRIGFT SSAPFIRAVS DTLSLFRRDY
     PDVHLQTREM NTREQIAPLI EGTLDMGLLR NTALPESLEH AVIVHEPLMA MIPHDHPLAN
     NPNVTLAELA KEPFVFFDPH VGTGLYDDIL GLMRRYHLTP VITQEVGEAM TIIGLVSAGL
     GVSILPASFK RVQLNEMRWV PIAEEDAVSE MWLVWPKHHE QSPAARNFRI HLLNALR