YNFM_ECOLI
ID YNFM_ECOLI Reviewed; 417 AA.
AC P43531; P76886; P77705;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Inner membrane transport protein YnfM;
GN Name=ynfM; Synonyms=yzyC; OrderedLocusNames=b1596, JW1588;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097039; DOI=10.1093/dnares/3.6.363;
RA Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M., Makino K.,
RA Miki T., Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S.,
RA Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G.,
RA Seki Y., Sivasundaram S., Tagami H., Takeda J., Takemoto K., Takeuchi Y.,
RA Wada C., Yamamoto Y., Horiuchi T.;
RT "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 28.0-40.1 min region on the linkage map.";
RL DNA Res. 3:363-377(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 350-417.
RC STRAIN=K12 / N2212;
RA Jakubcionyte E., Apirion D., Normark S.;
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION.
RA Rudd K.E.;
RL Unpublished observations (JUL-1995).
RN [6]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; U00096; AAC74668.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15330.1; -; Genomic_DNA.
DR EMBL; AF405541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; F64915; F64915.
DR RefSeq; NP_416113.1; NC_000913.3.
DR RefSeq; WP_000091840.1; NZ_SSZK01000001.1.
DR AlphaFoldDB; P43531; -.
DR SMR; P43531; -.
DR BioGRID; 4259121; 157.
DR STRING; 511145.b1596; -.
DR TCDB; 2.A.1.36.1; the major facilitator superfamily (mfs).
DR PaxDb; P43531; -.
DR PRIDE; P43531; -.
DR EnsemblBacteria; AAC74668; AAC74668; b1596.
DR EnsemblBacteria; BAA15330; BAA15330; BAA15330.
DR GeneID; 66674514; -.
DR GeneID; 946138; -.
DR KEGG; ecj:JW1588; -.
DR KEGG; eco:b1596; -.
DR PATRIC; fig|1411691.4.peg.666; -.
DR EchoBASE; EB2785; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_001265_19_3_6; -.
DR InParanoid; P43531; -.
DR OMA; LYCVQPM; -.
DR PhylomeDB; P43531; -.
DR BioCyc; EcoCyc:B1596-MON; -.
DR PRO; PR:P43531; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..417
FT /note="Inner membrane transport protein YnfM"
FT /id="PRO_0000173411"
FT TOPO_DOM 1..38
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..73
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..101
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..152
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 174..190
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..241
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..315
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..387
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 409..417
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 45258 MW; 78862FD89AD1987B CRC64;
MSRTTTVDGA PASDTDKQSI SQPNQFIKRG TPQFMRVTLA LFSAGLATFA LLYCVQPILP
VLSQEFGLTP ANSSISLSIS TAMLAIGLLF TGPLSDAIGR KPVMVTALLL ASICTLLSTM
MTSWHGILIM RALIGLSLSG VAAVGMTYLS EEIHPSFVAF SMGLYISGNS IGGMSGRLIS
GVFTDFFNWR IALAAIGCFA LASALMFWKI LPESRHFRPT SLRPKTLFIN FRLHWRDRGL
PLLFAEGFLL MGSFVTLFNY IGYRLMLSPW HVSQAVVGLL SLAYLTGTWS SPKAGTMTTR
YGRGPVMLFS TGVMLFGLLM TLFSSLWLIF AGMLLFSAGF FAAHSVASSW IGPRAKRAKG
QASSLYLFSY YLGSSIAGTL GGVFWHNYGW NGVGAFIALM LVIALLVGTR LHRRLHA
