ID   YNGE_BACSU              Reviewed;         511 AA.
AC   O31825; Q799L5;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Uncharacterized carboxylase YngE;
DE            EC=6.4.1.-;
GN   Name=yngE; OrderedLocusNames=BSU18210;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-282.
RC   STRAIN=168;
RX   PubMed=9387222; DOI=10.1099/00221287-143-11-3443;
RA   Tosato V., Albertini A.M., Zotti M., Sonda S., Bruschi C.V.;
RT   "Sequence completion, identification and definition of the fengycin operon
RT   in Bacillus subtilis 168.";
RL   Microbiology 143:3443-3450(1997).
CC   -!- SIMILARITY: Belongs to the AccD/PCCB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA74219.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL009126; CAB13704.2; -; Genomic_DNA.
DR   EMBL; Y13917; CAA74219.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_389703.2; NC_000964.3.
DR   RefSeq; WP_003231527.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O31825; -.
DR   SMR; O31825; -.
DR   STRING; 224308.BSU18210; -.
DR   PaxDb; O31825; -.
DR   PRIDE; O31825; -.
DR   EnsemblBacteria; CAB13704; CAB13704; BSU_18210.
DR   GeneID; 939528; -.
DR   KEGG; bsu:BSU18210; -.
DR   PATRIC; fig|224308.43.peg.1930; -.
DR   eggNOG; COG4799; Bacteria.
DR   InParanoid; O31825; -.
DR   OMA; AYLPIMS; -.
DR   PhylomeDB; O31825; -.
DR   BioCyc; BSUB:BSU18210-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:1905202; C:methylcrotonoyl-CoA carboxylase complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006552; P:leucine catabolic process; IBA:GO_Central.
DR   InterPro; IPR034733; AcCoA_carboxyl.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   InterPro; IPR045190; MCCB/AccD1-like.
DR   PANTHER; PTHR22855; PTHR22855; 1.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   SUPFAM; SSF52096; SSF52096; 2.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..511
FT                   /note="Uncharacterized carboxylase YngE"
FT                   /id="PRO_0000389136"
FT   DOMAIN          2..254
FT                   /note="CoA carboxyltransferase N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01136"
FT   DOMAIN          260..506
FT                   /note="CoA carboxyltransferase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01137"
FT   REGION          2..506
FT                   /note="Carboxyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01138"
SQ   SEQUENCE   511 AA;  56182 MW;  8225CEBA8B700A45 CRC64;
     MLMDYEKERT ERAERIRKGG AEKYHQSNRE KGKLFVRERL SLLFDDDIEL EDAFFAECMS
     DGLPADGVVT AIGKIGGQTV CVMANDSTVK AGSWGAKTVE KIIRIQEIAE KLNCPLIYLV
     DSAGARITDQ INVFPGRRGA GRIFYNQVKL SGRIPQICLL FGPSAAGGAY IPAFCDIVVM
     VDGNASMYLG SPRMAEMVIG EKVSLEEMGG ARMHCSISGC GDILAETEEE AIQLVRAYLS
     YFPANFQEKA PIHEKRPPKH FETPLADVIP QNQNAPFDMH ELIERVIDED SFFEIKALFA
     PELLTGLARI HGQPVGIVAN QPKVKGGVLF HDSADKAAKF ITLCDAFHIP LLFLADIPGF
     MIGTKVEQAG IIRHGAKMIS AMSEATVPKL SVIVRKAYGA GLYAMAGPAF EPDCCLALPT
     AQIAVMGPEA AVNAVYAKKI AELPEEERAA FISSKREEYK EDINIYRLAS EMIIDAVIPA
     NSLRDELAKR LKAYMTKEMT FTNRKHPVYP V