CBP4_YEAST
ID CBP4_YEAST Reviewed; 147 AA.
AC P37267; D6VUV8; Q6TQT9; Q6TQU0;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 3.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Assembly factor CBP4;
DE AltName: Full=Cytochrome b mRNA-processing protein 4;
GN Name=CBP4; OrderedLocusNames=YGR174C; ORFNames=G7122;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=8063753; DOI=10.1016/s0021-9258(17)31961-0;
RA Crivellone M.D.;
RT "Characterization of CBP4, a new gene essential for the expression of
RT ubiquinol-cytochrome c reductase in Saccharomyces cerevisiae.";
RL J. Biol. Chem. 269:21284-21292(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-43 AND 91-147.
RC STRAIN=ATCC 204511 / S288c / AB972;
RA Kennedy M.C., Dietrich F.S.;
RT "Verification of 3' and 5' ends of S.cerevisiae transcripts.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [9]
RP FUNCTION, AND INTERACTION WITH CBP3.
RX PubMed=15759116; DOI=10.1007/s00294-005-0561-9;
RA Kronekova Z., Rodel G.;
RT "Organization of assembly factors Cbp3p and Cbp4p and their effect on bc(1)
RT complex assembly in Saccharomyces cerevisiae.";
RL Curr. Genet. 47:203-212(2005).
CC -!- FUNCTION: Essential for the assembly of ubiquinol-cytochrome c
CC reductase. It has a direct effect on the correct occurrence of the
CC Rieske protein, core 4, core 5 and apocytochrome b.
CC {ECO:0000269|PubMed:15759116, ECO:0000269|PubMed:8063753}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Single-pass membrane protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 704 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the CBP4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA61566.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAT93181.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA97200.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=DAA08269.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U10700; AAA61566.1; ALT_INIT; Genomic_DNA.
DR EMBL; Z72959; CAA97200.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY693162; AAT93181.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY389299; AAQ97231.1; -; mRNA.
DR EMBL; AY389298; AAQ97230.1; -; mRNA.
DR EMBL; BK006941; DAA08269.1; ALT_INIT; Genomic_DNA.
DR PIR; S64488; S64488.
DR RefSeq; NP_011690.3; NM_001181303.3.
DR AlphaFoldDB; P37267; -.
DR SMR; P37267; -.
DR BioGRID; 33427; 287.
DR DIP; DIP-4216N; -.
DR IntAct; P37267; 4.
DR MINT; P37267; -.
DR STRING; 4932.YGR174C; -.
DR MaxQB; P37267; -.
DR PaxDb; P37267; -.
DR PRIDE; P37267; -.
DR GeneID; 853085; -.
DR KEGG; sce:YGR174C; -.
DR SGD; S000003406; CBP4.
DR eggNOG; ENOG502S2G8; Eukaryota.
DR HOGENOM; CLU_147520_0_0_1; -.
DR InParanoid; P37267; -.
DR BioCyc; YEAST:G3O-30870-MON; -.
DR PRO; PR:P37267; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P37267; protein.
DR GO; GO:0032592; C:integral component of mitochondrial membrane; IDA:SGD.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; IMP:SGD.
DR InterPro; IPR012420; Cbp4.
DR PANTHER; PTHR28202; PTHR28202; 1.
DR Pfam; PF07960; CBP4; 1.
PE 1: Evidence at protein level;
KW Chaperone; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..147
FT /note="Assembly factor CBP4"
FT /id="PRO_0000020845"
FT TRANSMEM 5..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 73..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 42
FT /note="S -> F (in Ref. 1; AAA61566)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 147 AA; 17532 MW; 27CD71BD4C7CE8BB CRC64;
MERPLWVRWL KVYAIGGAII GSGFLLFKYT TPTDQQLISQ LSPELRLQYE REKKLRQSEQ
QALMKIVKET SQSDDPIWKT GPLQSPWERN GDNVQSRDHF AKVRAEEVQK EELARIRNEL
SQLRSETEEK TKEIVQDKQV KSWWRFW
