CBP6_YEAST
ID CBP6_YEAST Reviewed; 162 AA.
AC P07253; D6VQB8; E9P8V5;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Cytochrome B pre-mRNA-processing protein 6;
GN Name=CBP6; OrderedLocusNames=YBR120C; ORFNames=YBR0916;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=2981859; DOI=10.1016/s0021-9258(18)89622-3;
RA Dieckmann C.L., Tzagoloff A.;
RT "Assembly of the mitochondrial membrane system. CBP6, a yeast nuclear gene
RT necessary for synthesis of cytochrome b.";
RL J. Biol. Chem. 260:1513-1520(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7900426; DOI=10.1002/yea.320101014;
RA Mannhaupt G., Stucka R., Ehnle S., Vetter I., Feldmann H.;
RT "Analysis of a 70 kb region on the right arm of yeast chromosome II.";
RL Yeast 10:1363-1381(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-97, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=17761666; DOI=10.1074/mcp.m700098-mcp200;
RA Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,
RA van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
RT "Profiling phosphoproteins of yeast mitochondria reveals a role of
RT phosphorylation in assembly of the ATP synthase.";
RL Mol. Cell. Proteomics 6:1896-1906(2007).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: This protein is involved in processing of the 5' terminus and
CC the intervening sequences of cytochrome b pre-mRNA.
CC {ECO:0000269|PubMed:2981859}.
CC -!- INTERACTION:
CC P07253; P21560: CBP3; NbExp=4; IntAct=EBI-4142, EBI-4134;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:14576278}.
CC -!- MISCELLANEOUS: Present with 2130 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; M10154; AAA34476.1; -; Genomic_DNA.
DR EMBL; X78993; CAA55622.1; -; Genomic_DNA.
DR EMBL; Z35989; CAA85077.1; -; Genomic_DNA.
DR EMBL; AY558183; AAS56509.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07238.1; -; Genomic_DNA.
DR PIR; A22596; A22596.
DR RefSeq; NP_009678.3; NM_001178468.3.
DR AlphaFoldDB; P07253; -.
DR BioGRID; 32822; 94.
DR ComplexPortal; CPX-384; CBP3-CBP6 complex.
DR DIP; DIP-5707N; -.
DR IntAct; P07253; 4.
DR MINT; P07253; -.
DR STRING; 4932.YBR120C; -.
DR iPTMnet; P07253; -.
DR MaxQB; P07253; -.
DR PaxDb; P07253; -.
DR PRIDE; P07253; -.
DR EnsemblFungi; YBR120C_mRNA; YBR120C; YBR120C.
DR GeneID; 852417; -.
DR KEGG; sce:YBR120C; -.
DR SGD; S000000324; CBP6.
DR VEuPathDB; FungiDB:YBR120C; -.
DR eggNOG; ENOG502SAQZ; Eukaryota.
DR HOGENOM; CLU_149479_0_0_1; -.
DR InParanoid; P07253; -.
DR OMA; INRTSGP; -.
DR BioCyc; YEAST:G3O-29077-MON; -.
DR PRO; PR:P07253; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P07253; protein.
DR GO; GO:0061671; C:Cbp3p-Cbp6 complex; IPI:SGD.
DR GO; GO:0005761; C:mitochondrial ribosome; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; IDA:ComplexPortal.
DR GO; GO:0043022; F:ribosome binding; IDA:SGD.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; IDA:ComplexPortal.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0070131; P:positive regulation of mitochondrial translation; IMP:SGD.
DR GO; GO:0050821; P:protein stabilization; IDA:ComplexPortal.
DR InterPro; IPR037653; Cbp6.
DR PANTHER; PTHR28250; PTHR28250; 1.
PE 1: Evidence at protein level;
KW Acetylation; Mitochondrion; mRNA processing; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..162
FT /note="Cytochrome B pre-mRNA-processing protein 6"
FT /id="PRO_0000089381"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 97
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17761666"
FT CONFLICT 2
FT /note="S -> Y (in Ref. 5; AAS56509)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 162 AA; 18679 MW; C8F5D171CDF7DD70 CRC64;
MSSSQVVRDS AKKLVNLLEK YPKDRIHHLV SFRDVQIARF RRVAGLPNVD DKGKSIKEKK
PSLDEIKSII NRTSGPLGLN KEMLTKIQNK MVDEKFTEES INEQIRALST IMNNKFRNYY
DIGDKLYKPA GNPQYYQRLI NAVDGKKKES LFTAMRTVLF GK
