YNV7_YEAST
ID YNV7_YEAST Reviewed; 326 AA.
AC P40152; D6W0X3;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Putative metallophosphoesterase YNL217W;
DE EC=3.1.-.-;
DE Flags: Precursor;
GN OrderedLocusNames=YNL217W; ORFNames=N1306;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=7762305; DOI=10.1002/yea.320110111;
RA Coster F., van Dyck L., Jonniaux J.-L., Purnelle B., Goffeau A.;
RT "The sequence of a 13.5 kb DNA segment from the left arm of yeast
RT chromosome XIV reveals MER1; RAP1; a new putative member of the DNA
RT replication complex and a new putative serine/threonine phosphatase gene.";
RL Yeast 11:85-91(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP PROTEIN SEQUENCE OF 149-168; 257-272 AND 313-326, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RA Bienvenut W.V., Peters C.;
RL Submitted (JUN-2005) to UniProtKB.
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
CC -!- SUBCELLULAR LOCATION: Vacuole {ECO:0000269|PubMed:14562095}.
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC {ECO:0000305}.
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DR EMBL; X78898; CAA55490.1; -; Genomic_DNA.
DR EMBL; Z71493; CAA96119.1; -; Genomic_DNA.
DR EMBL; AY558018; AAS56344.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10339.1; -; Genomic_DNA.
DR PIR; S50713; S50713.
DR RefSeq; NP_014182.1; NM_001183055.1.
DR AlphaFoldDB; P40152; -.
DR SMR; P40152; -.
DR BioGRID; 35619; 51.
DR DIP; DIP-4934N; -.
DR IntAct; P40152; 8.
DR MINT; P40152; -.
DR STRING; 4932.YNL217W; -.
DR MaxQB; P40152; -.
DR PaxDb; P40152; -.
DR PRIDE; P40152; -.
DR EnsemblFungi; YNL217W_mRNA; YNL217W; YNL217W.
DR GeneID; 855504; -.
DR KEGG; sce:YNL217W; -.
DR SGD; S000005161; YNL217W.
DR VEuPathDB; FungiDB:YNL217W; -.
DR eggNOG; KOG0371; Eukaryota.
DR HOGENOM; CLU_023125_0_1_1; -.
DR InParanoid; P40152; -.
DR OMA; SACLYGH; -.
DR BioCyc; YEAST:G3O-33223-MON; -.
DR BRENDA; 3.6.1.10; 984.
DR PRO; PR:P40152; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P40152; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000324; C:fungal-type vacuole; IDA:SGD.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:SGD.
DR GO; GO:0005775; C:vacuolar lumen; IDA:SGD.
DR GO; GO:0000298; F:endopolyphosphatase activity; IDA:SGD.
DR GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR GO; GO:0006798; P:polyphosphate catabolic process; IDA:SGD.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Hydrolase; Reference proteome; Signal; Vacuole.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..326
FT /note="Putative metallophosphoesterase YNL217W"
FT /id="PRO_0000042987"
SQ SEQUENCE 326 AA; 37151 MW; D69F22A94C4C6684 CRC64;
MEDKRKRRAA TLSTALILFV ACCVYTLYIF KFDNPRLSPP VSLLPTISTL KKIEHVTDLN
KEYVFVGDVH GNYDEFIELI DDKIGGLGEN ITMILLGDFI HKGPDSDKVV SYILNHKDQV
KCVLGNHEIL VMMAYLNPDF SKWVRRPKLM TPLTFSTETN FIPQDISKIS NAHGRLAREL
GFSKLSQLAE HCSMAIELDL DITGDILFGA HAGMVPGDFM KPNQIPGVSS LSNMKYVDKK
NWSKTSREKE NKNYVRWYTL WDKYGDHFSN AKVFYGHDAS MGLNLRRQTK GLDTACIKNN
LLSSMKVKYD IKKGQYDYEL IQVQCS
