YO093_YEAST
ID YO093_YEAST Reviewed; 1648 AA.
AC Q12275; D6W2F4;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Uncharacterized protein YOR093C;
GN OrderedLocusNames=YOR093C; ORFNames=YOR3170c;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=9200815;
RX DOI=10.1002/(sici)1097-0061(19970615)13:7<655::aid-yea120>3.0.co;2-i;
RA Voss H., Benes V., Andrade M.A., Valencia A., Rechmann S., Teodoru C.,
RA Schwager C., Paces V., Sander C., Ansorge W.;
RT "DNA sequencing and analysis of 130 kb from yeast chromosome XV.";
RL Yeast 13:655-672(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-751, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ADR376;
RX PubMed=17330950; DOI=10.1021/pr060559j;
RA Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,
RA Elias J.E., Gygi S.P.;
RT "Large-scale phosphorylation analysis of alpha-factor-arrested
RT Saccharomyces cerevisiae.";
RL J. Proteome Res. 6:1190-1197(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 41 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X94335; CAA64015.1; -; Genomic_DNA.
DR EMBL; Z75001; CAA99290.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10870.1; -; Genomic_DNA.
DR PIR; S61654; S61654.
DR RefSeq; NP_014736.1; NM_001183512.1.
DR AlphaFoldDB; Q12275; -.
DR SMR; Q12275; -.
DR BioGRID; 34491; 76.
DR DIP; DIP-2646N; -.
DR IntAct; Q12275; 4.
DR MINT; Q12275; -.
DR STRING; 4932.YOR093C; -.
DR iPTMnet; Q12275; -.
DR MaxQB; Q12275; -.
DR PaxDb; Q12275; -.
DR PRIDE; Q12275; -.
DR EnsemblFungi; YOR093C_mRNA; YOR093C; YOR093C.
DR GeneID; 854260; -.
DR KEGG; sce:YOR093C; -.
DR SGD; S000005619; YOR093C.
DR VEuPathDB; FungiDB:YOR093C; -.
DR eggNOG; KOG3628; Eukaryota.
DR GeneTree; ENSGT00950000182997; -.
DR HOGENOM; CLU_000737_0_0_1; -.
DR InParanoid; Q12275; -.
DR OMA; TIMGMCK; -.
DR BioCyc; YEAST:G3O-33627-MON; -.
DR PRO; PR:Q12275; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q12275; protein.
DR GO; GO:0005935; C:cellular bud neck; HDA:SGD.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd05905; Dip2; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; -; 3.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR037337; Dip2-like_dom.
DR InterPro; IPR010506; DMAP1-bd.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF06464; DMAP_binding; 1.
DR SMART; SM01137; DMAP_binding; 1.
DR PROSITE; PS51912; DMAP1_BIND; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1648
FT /note="Uncharacterized protein YOR093C"
FT /id="PRO_0000237653"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1061..1081
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1224..1244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 5..101
FT /note="DMAP1-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01260"
FT REGION 52..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 99
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
FT MOD_RES 751
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17330950"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 575
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 644
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 730
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 881
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 917
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 995
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1009
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1302
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1447
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1472
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1488
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1565
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1597
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1634
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1648 AA; 186907 MW; 961796ECDF51CCF1 CRC64;
MDFSIPPTLP LDLQSRLNEL IQDYKDENLT RKGYETKRKQ LLDKFEISQM RPYTPLRSPN
SRKSKHLHRR NTSLASSITS LPNSIDRRHS IYRVTTINST SANNTPRRRS KRYTASLQSS
LPGSSDENGS VKDAVYNPMI PLLPRHTGAE NTSSGDSAMT DSLPLILRGR FEHYDGQTAM
ISINSKGKET FITWDKLYLK AERVAHELNK SHLYKMDKIL LWYNKNDVIE FTIALLGCFI
SGMAAVPVSF ETYSLREILE IIKVTNSKFV LISNACHRQL DNLYSSSNHS KVKLVKNDVF
QQIKFVKTDD LGTYTKAKKT SPTFDIPNIS YIEFTRTPLG RLSGVVMKHN ILINQFETMT
KILNSRSMPH WKQKSQSIRK PFHKKIMATN SRFVILNSLD PTRSTGLIMG VLFNLFTGNL
MISIDSSILQ RPGGYENIID KFRADILLND QLQLKQVVIN YLENPESAFS KKHKIDFSCI
KSCLTSCTTI DTDVSEMVVH KWLKNLGCID APFCYSPMLT LLDFGGIFIS IRDQLGNLEN
FPIHNSKLRL QNELFINREK LKLNEVECSI TAMINSSSSF KDYLKLETFG FPIPDITLCV
VNPDTNTLVQ DLTVGEIWIS SNHITDEFYQ MDKVNEFVFK AKLNYSEMFS WAKYEMPTNE
KSQAVTEQLD TILNICPANT YFMRTKLMGF VHNGKIYVLS LIEDMFLQNR LIRLPNWAHT
SNLLYAKKGN QSAQPKGNTG AESTKAIDIS SLSGETSSGY KRVVESHYLQ QITETVVRTV
NTVFEVAAFE LQHHKEEHFL VMVVESSLAK TEEESKNGET TDTTLMKFAE TQRNKLETKM
NDLTDQIFRI LWIFHKIQPM CILVVPRDTL PRRYCSLELA NSTVEKKFLN NDLSAQFVKF
QFDNVILDFL PHSAYYNESI LSEHLSKLRK MALQEEYAMI EPAYRNGGPV KPKLALQCSG
VDYRDESVDT RSHTKLTDFK SILEILEWRI SNYGNETAFS DGTNTNLVNS SASNDNNVHK
KVSWASFGKI VAGFLKKIVG SKIPLKHGDP IIIMCENSVE YVAMIMACLY CNLLVIPLPS
VKESVIEEDL KGLVNIIQSY KVKRVFVDAK LHSLLNDNNV VNKCFKKYKS LIPKITVFSK
VKTKNALTVS MFKNVLKQKF GAKPGTRIGM TPCVVWVNTE YDVTSNIHVT MTHSSLLNAS
KIVKETLQLR NNSPLFSICS HTSGLGFMFS CLLGIYTGAS TCLFSLTDVL TDPKEFLIGL
QNLNVKDLYL KLETLYALLD RASSLIEGFK NKKENINSAK NNTSGSLRED VFKGVRNIMI
PFPNRPRIYT IENILKRYST ISLSCTQISY VYQHHFNPLI SLRSYLDIPP VDLYLDPFSL
REGIIREVNP NDVSAGNYIK IQDSGVVPVC TDVSVVNPET LLPCVDGEFG EIWCCSEANA
FDYFVCNSSK NKLYKDPFIT EQFKSKMKSE VNNTLSYLRT GDLGFIKNVS CTNSQGEVVN
LNLLFVLGSI HESIEILGLT HFVSDLERTV KDVHSDIGSC LIAKAGGLLV CLIRCKERHN
PILGNLTTLI VSELLNKHGV ILDLCTFVRT KGISPKNSSM IMEVWAKNRA SIMQAWFDQK
IQIEAQFGIN YGENISIYLL SDYEKDNI
