YO12_CAEEL
ID YO12_CAEEL Reviewed; 593 AA.
AC P34668;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 24-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Putative ATP-dependent RNA helicase ZK686.2;
DE EC=3.6.4.13;
GN ORFNames=ZK686.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Probable ATP-binding RNA helicase.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. {ECO:0000305}.
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DR EMBL; FO080431; CCD63647.1; -; Genomic_DNA.
DR PIR; D88511; D88511.
DR PIR; S44912; S44912.
DR RefSeq; NP_498690.2; NM_066289.5.
DR AlphaFoldDB; P34668; -.
DR SMR; P34668; -.
DR STRING; 6239.ZK686.2; -.
DR iPTMnet; P34668; -.
DR EPD; P34668; -.
DR PaxDb; P34668; -.
DR PeptideAtlas; P34668; -.
DR EnsemblMetazoa; ZK686.2.1; ZK686.2.1; WBGene00022792.
DR GeneID; 176088; -.
DR KEGG; cel:CELE_ZK686.2; -.
DR UCSC; ZK686.2; c. elegans.
DR CTD; 176088; -.
DR WormBase; ZK686.2; CE34464; WBGene00022792; -.
DR eggNOG; KOG0350; Eukaryota.
DR GeneTree; ENSGT00550000075141; -.
DR HOGENOM; CLU_003041_15_3_1; -.
DR InParanoid; P34668; -.
DR OMA; KFHPLAV; -.
DR OrthoDB; 973872at2759; -.
DR PhylomeDB; P34668; -.
DR PRO; PR:P34668; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00022792; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043186; C:P granule; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome;
KW RNA-binding.
FT CHAIN 1..593
FT /note="Putative ATP-dependent RNA helicase ZK686.2"
FT /id="PRO_0000055095"
FT DOMAIN 150..341
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 386..533
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 377..380
FT /note="DEAD box"
FT COMPBIAS 42..65
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 163..170
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 593 AA; 66545 MW; B13AB2CB7032E748 CRC64;
MKRKNQKEDS DTENDDEIEP ANGDGIEQEM NRVTNGNEDD ESVGNDVAEP METEDVEDSG
EVEIEETAQN GEREIFKVLG KQEMKNLEAL KVTSSWVQNA TTFSATIDSS TSQKLSQIEL
PEHLTVPSAI STWFPVQYAV LPSLFFEIRS PPPLRPRDVA IAAPTGSGKT ICYVLPVLAA
VGSKPSKILQ AVILVPVQTL VAQIVDEFKR WNDESGVAKV VSLSGANDFE KEARQLASDP
PNVIVATPAR LVQHLTSKIP PPIDLSKLRF LIVDEADRMG KLMREEWLDL VEFLCGGMER
VACLKDIIRQ RRAPQKIVLS ATLSKDVEEL HLWNLFKPRL FSATAVSVKD ITSGIPQVDH
VSGRLALPSS ISHRLVVTDP KFHPLAVYQQ ITRNKFNRTL IFVNEVSSSN RLAHVLKELC
KDQFEVDYFT AQLFGKRRYK MLEKFNKNEN RVLICSDVLA RGTDLNKVDC VINYNLPADD
KLFVHRAGRT GRAGQDGYVI SVGDKESKRL FVKMLKVTNL WGDTVEEQME EYIFEKDMDR
YSKALESLKA TVSSQAKTGG SRQIAKRSGF EAKRKSRPNA RGEKPWLKKK TTE
