YO25_CAEEL
ID YO25_CAEEL Reviewed; 1620 AA.
AC P34675; Q8I7F0;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Uncharacterized protein ZK688.5;
GN ORFNames=ZK688.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P34675-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34675-2; Sequence=VSP_017897;
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DR EMBL; FO080277; CCD62536.1; -; Genomic_DNA.
DR EMBL; FO080277; CCD62537.1; -; Genomic_DNA.
DR PIR; S44920; S44920.
DR RefSeq; NP_498714.1; NM_066313.5.
DR RefSeq; NP_871663.1; NM_181934.4.
DR AlphaFoldDB; P34675; -.
DR SMR; P34675; -.
DR BioGRID; 41315; 1.
DR STRING; 6239.ZK688.5a; -.
DR iPTMnet; P34675; -.
DR EPD; P34675; -.
DR PaxDb; P34675; -.
DR PeptideAtlas; P34675; -.
DR EnsemblMetazoa; ZK688.5a.1; ZK688.5a.1; WBGene00022800.
DR EnsemblMetazoa; ZK688.5b.1; ZK688.5b.1; WBGene00022800.
DR UCSC; ZK688.5a; c. elegans. [P34675-1]
DR WormBase; ZK688.5a; CE29166; WBGene00022800; -. [P34675-1]
DR WormBase; ZK688.5b; CE33264; WBGene00022800; -. [P34675-2]
DR eggNOG; KOG4248; Eukaryota.
DR GeneTree; ENSGT00390000016199; -.
DR HOGENOM; CLU_243574_0_0_1; -.
DR InParanoid; P34675; -.
DR OMA; MIVRVPS; -.
DR OrthoDB; 397352at2759; -.
DR PRO; PR:P34675; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00022800; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; P34675; baseline and differential.
DR GO; GO:0071818; C:BAT3 complex; IBA:GO_Central.
DR GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..1620
FT /note="Uncharacterized protein ZK688.5"
FT /id="PRO_0000065545"
FT DOMAIN 21..96
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT REGION 621..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..1016
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1561..1575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1581..1620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1560..1620
FT /note="RKRNHDGSREDNDDCVDVVAPMMTSLSTSSPLTSQSSSSGTRTSSGSSGPST
FT SSTTTNNIQ -> SLGRLIWTQIRRFFQENAITTAVARIMMTVWMWWHR (in
FT isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_017897"
SQ SEQUENCE 1620 AA; 181559 MW; A954ABC7FF73EF30 CRC64;
MSETQEQEAS GNGEPDLPTT IRVTLKTLDD REATVTIGLQ DTIQSLIDLG RREMNIQSGF
QRVIAGGRVL NSTQTVQAAG ISDGQTVHLV DRGPSGENDR PNVMPDRVAG PRIINAIPGL
PPPGFIFQSP AFARMIPGNV EIPTPPSQTQ HTVVHPIRVP GSIAGTPVLT SRVSEDCVLQ
KAVPYRGTSN SPNRPQAASQ TVTFPSEPNV IQWTVNIADD LIFRPREHFE QVVRETINNI
SFLSDSTRLG VSMKWNQNCT SLSVELPPVS PHIPSPALEK LDFLCLWTDH LSRFIDKLEE
HDGLVAATRH VLEMVKTRQF DQNLSQQARN QRVEALDEIV KHLEYQWAEL SHMKDFERIR
FRKNQTEEYR ALKIQEYPET PRNPHFYMRH ALDIDVIGVM REFRKQQRRF TRLEDLLDDL
NEVGAVKFIR DHITTEVDYR YQALSMFYCY IQRMRHQISH MTHLTADLDV SFITPSFPQR
ILPQYAFQSS DEQPLTIPVT HIFEPPRMLS DVGGRYNGDY PYLAYHPPSV HMEVVLQEPR
RIAEPRPQIL ARPTPQQFVL TQEMNQGGSI NLMAATDPIS GLSLQDVLRA QQEQVENLFA
QQPGIEGGRV RVTARPGRRF VATTGDAPSV PVETLPPPGS DQQPGTSRRF TTHRFNVQPD
ARGAETETLA PFPVAIEPNE LQRIAKNIAS RYRAEALQRI ASSLTTRFNN ESWDTRIQNM
PLCTLRECVA IALEMLTSAG NTVNESKDLM LALVRDEEVL VRAIAECIKS LFGRGEFPTH
VARLIMPTNQ TASSRNDYES VDGVEESQSD EFDSMIVRVP SDISQPQSGD LRAIRERRQN
RRQFLENRGR IPSTSSAPST SENPPGPSFN SEDAADIRAG RLPLGTRPNR RTVRETVHPA
AAARAESPNH ISLTFTATTH TFAPAGFPLM MASSNVPSTS AGPPGWPIRQ VVSPTPTTRG
LFEFDLSGSS DQPARSTPSP PAPTPRTTSA PATVQSSPTR QESMDIDSPN VQNPGHVESP
AAIAARQAAR VARARIDHLA ATFNGDLADS RRQSPFVTPG PTTPLNDPRR RTVRVTQHVK
PMVAIDPFMN CTNRHCEINR LATPTHMADG DRFTLQSLQP DQEFEARIQA LVPSIERRPI
QIHHEDEDYN YSIRRTQSGL LSFRNLEDFR PFVKTAIRSL LAHCIDADTL FTMNMNNISG
YQAANHTELL RMVKEHISRV PGSRATRNAS QNTTSVNQST ETSPREQMNR SPVQEAADPR
LAFSPFPPGI NLEQEVLIPG QIASLLTYLV DYMESSSNPR PPGIFGFLLE LTYGRLTRHD
FAQLARRTTA TNVASEFEAQ IRAHIRDNYL VGRTGLSNSE LHGIAENLAN NEQFFAIFMS
QNDQLPTSFP FGYDRNDFAE VVWAFRQIEI ALIKSFLTLS QLNLDSGNAV RFILQSVDSY
LYRNLIMFYR MCDRDVERMK IQMKRISDYF ATIRYESTDR PGINVFIDNW NRVMDYWSNR
YTDFSEENFD QFLLKVRAGT DWNDIVLNES RQLLPTIAST SSQPSTSSSS LNTVSTNNPR
KRNHDGSRED NDDCVDVVAP MMTSLSTSSP LTSQSSSSGT RTSSGSSGPS TSSTTTNNIQ
