YO365_YEAST
ID YO365_YEAST Reviewed; 703 AA.
AC Q08844; D6W359;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Uncharacterized membrane protein YOR365C;
DE Flags: Precursor;
GN OrderedLocusNames=YOR365C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the transient receptor potential (TRP) ion
CC channel family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z75272; CAA99695.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA11125.1; -; Genomic_DNA.
DR PIR; S67277; S67277.
DR RefSeq; NP_015010.1; NM_001183785.1.
DR AlphaFoldDB; Q08844; -.
DR BioGRID; 34749; 63.
DR IntAct; Q08844; 1.
DR MINT; Q08844; -.
DR STRING; 4932.YOR365C; -.
DR PaxDb; Q08844; -.
DR PRIDE; Q08844; -.
DR EnsemblFungi; YOR365C_mRNA; YOR365C; YOR365C.
DR GeneID; 854548; -.
DR KEGG; sce:YOR365C; -.
DR SGD; S000005892; YOR365C.
DR VEuPathDB; FungiDB:YOR365C; -.
DR eggNOG; ENOG502QSVZ; Eukaryota.
DR GeneTree; ENSGT00940000176312; -.
DR HOGENOM; CLU_010226_0_1_1; -.
DR InParanoid; Q08844; -.
DR OMA; QDILTWY; -.
DR BioCyc; YEAST:G3O-33834-MON; -.
DR PRO; PR:Q08844; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08844; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0009272; P:fungal-type cell wall biogenesis; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR InterPro; IPR010308; TRP_C.
DR InterPro; IPR040241; TRP_Flc/Pkd2-like.
DR InterPro; IPR032800; TRP_N.
DR PANTHER; PTHR31145; PTHR31145; 1.
DR Pfam; PF06011; TRP; 1.
DR Pfam; PF14558; TRP_N; 1.
DR SMART; SM01320; TRP_N; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..703
FT /note="Uncharacterized membrane protein YOR365C"
FT /id="PRO_0000252268"
FT TOPO_DOM 25..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..374
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..415
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 439..452
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 474..516
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 517..537
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 538..545
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 546..566
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 567..571
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 572..592
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 593..605
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 606..626
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 627..703
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 703 AA; 80285 MW; DCCFECDF6BFD1FBF CRC64;
MLPIKVFSLS RIFVLLAIFR QIHAISINSS TFQVSNSFTL LNNASTLFPV PFDAYTKEYL
RTSALLTCAK DSQFSASYFE AAFFPRNNTL FFNVEAQTIM SENITIKAEL IAYGLNVYTK
VFDLCGIQDN LLCPLKPGNI ELMGSYYVEA AVASQIPSIT YNIPDLDAYI VVTAYSTIDK
EFTKPLACVQ VMLSNGRTVQ TEYLSWNLVI LTISGIMFSV VYSLQGYTVT STRLASYSIS
LLLYFQNLAI LAMISVSFLP PIVAAWTQNF QWSMGIIRIN FMQRLFDWYV VATSGSPTVV
YRNKEVLSIS VQKRSLNSKI ISASSNLNGI ESSQKNDLLY TSNLRNSNDY LSKILVLRGI
KRVSYKAGIE ISNFFLTGFS FFIIFICMII LAFIIFKTFL KVLQKFKVKT IRYLHFHTHW
SALLQGTLYR AVFIIYSEIS LLALWEFTQT DSAATLVEAI VVFILITVLL SSASVRIWRK
MIKSKKIFGQ PSYLLFSSSK FLNKFGFLSS QFKSTKVWWL MATSAHMLIR SILVGSLQAH
GKSQSIGIFL NEAIYLILLC WMQPYMDKTT NFFNISIHSL NLVNAFFFLF FSNLFQQPIA
VSSFMGLIFF FLNAAFSLYL FIFILICFTM AIYYKHPDTR YKPIDDQRRS FLKGEMDDDA
VYESVPELHE MKKAVLECNG IQKPQINKID LCKQNSNCEY LYM
