ID   YO42_CAEEL              Reviewed;         294 AA.
AC   P34680;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Uncharacterized protein ZK757.2;
GN   ORFNames=ZK757.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class dual specificity subfamily. {ECO:0000305}.
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DR   EMBL; Z29121; CAA82388.2; -; Genomic_DNA.
DR   PIR; S41012; S41012.
DR   RefSeq; NP_499190.2; NM_066789.4.
DR   AlphaFoldDB; P34680; -.
DR   SMR; P34680; -.
DR   STRING; 6239.ZK757.2; -.
DR   PaxDb; P34680; -.
DR   EnsemblMetazoa; ZK757.2.1; ZK757.2.1; WBGene00014074.
DR   EnsemblMetazoa; ZK757.2.2; ZK757.2.2; WBGene00014074.
DR   GeneID; 191421; -.
DR   KEGG; cel:CELE_ZK757.2; -.
DR   UCSC; ZK757.2; c. elegans.
DR   CTD; 191421; -.
DR   WormBase; ZK757.2; CE34151; WBGene00014074; -.
DR   eggNOG; KOG1716; Eukaryota.
DR   HOGENOM; CLU_947413_0_0_1; -.
DR   InParanoid; P34680; -.
DR   OMA; VIWQELY; -.
DR   OrthoDB; 1576308at2759; -.
DR   PhylomeDB; P34680; -.
DR   PRO; PR:P34680; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00014074; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR   Pfam; PF00782; DSPc; 1.
DR   SMART; SM00195; DSPc; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protein phosphatase; Reference proteome.
FT   CHAIN           1..294
FT                   /note="Uncharacterized protein ZK757.2"
FT                   /id="PRO_0000094928"
FT   DOMAIN          13..151
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   REGION          234..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        95
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
SQ   SEQUENCE   294 AA;  32970 MW;  1F44393AADBEE7A3 CRC64;
     MTSRRIINRE QRQCSQIRPY LYVSGLAALS PRVLSRFCVC INLIPGFRLS APPHMKVVHL
     PLQDNETTDL SPHWANVYKE IEEARKGAGR ALLLCAMGIS RSATFGIAYV MQYEKKTLHD
     SYKAVQLARN IICPNVGFFQ QLIDLEQKLR GKVSCKIIEP LPGCKVPDVI WQELYDEMIM
     SMSQDDRHSL ASCNLSARST TNDTMSLRSL NMVNDTSRSL ASFHLTHRPI GASPTLLVPS
     SSSSSSVRGP IPLQRAHTEP PKEASILPKS ALRDKSKSGE KKKKWRLSFH KDVV