YO61_CAEEL
ID YO61_CAEEL Reviewed; 724 AA.
AC P34600; G3MTW8;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=WW domain-containing protein ZK1098.1;
GN ORFNames=ZK1098.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP INTERACTION WITH UNC-83.
RC STRAIN=Bristol N2;
RX PubMed=20005871; DOI=10.1016/j.ydbio.2009.12.004;
RA Fridolfsson H.N., Ly N., Meyerzon M., Starr D.A.;
RT "UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope
RT during nuclear migration.";
RL Dev. Biol. 338:237-250(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=P34600-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34600-2; Sequence=VSP_043943;
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DR EMBL; Z22176; CAA80142.1; -; Genomic_DNA.
DR EMBL; Z22176; CCD31169.1; -; Genomic_DNA.
DR PIR; F88557; F88557.
DR PIR; S40923; S40923.
DR RefSeq; NP_001255005.1; NM_001268076.1. [P34600-1]
DR RefSeq; NP_001255006.1; NM_001268077.1. [P34600-2]
DR AlphaFoldDB; P34600; -.
DR SMR; P34600; -.
DR BioGRID; 41538; 5.
DR STRING; 6239.ZK1098.1a; -.
DR iPTMnet; P34600; -.
DR EPD; P34600; -.
DR PaxDb; P34600; -.
DR PeptideAtlas; P34600; -.
DR PRIDE; P34600; -.
DR EnsemblMetazoa; ZK1098.1a.1; ZK1098.1a.1; WBGene00014218. [P34600-1]
DR EnsemblMetazoa; ZK1098.1b.1; ZK1098.1b.1; WBGene00014218. [P34600-2]
DR GeneID; 176343; -.
DR KEGG; cel:CELE_ZK1098.1; -.
DR UCSC; ZK1098.1; c. elegans. [P34600-1]
DR CTD; 176343; -.
DR WormBase; ZK1098.1a; CE03847; WBGene00014218; -. [P34600-1]
DR WormBase; ZK1098.1b; CE46142; WBGene00014218; -. [P34600-2]
DR eggNOG; KOG0152; Eukaryota.
DR GeneTree; ENSGT00930000150980; -.
DR HOGENOM; CLU_005825_0_1_1; -.
DR InParanoid; P34600; -.
DR OMA; NEPIYKH; -.
DR OrthoDB; 1112854at2759; -.
DR PhylomeDB; P34600; -.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:P34600; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00014218; Expressed in embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; HDA:WormBase.
DR GO; GO:0005685; C:U1 snRNP; IBA:GO_Central.
DR GO; GO:0071004; C:U2-type prespliceosome; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd00201; WW; 2.
DR Gene3D; 1.10.10.440; -; 5.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR039726; Prp40-like.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR11864; PTHR11864; 1.
DR Pfam; PF01846; FF; 4.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00441; FF; 5.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51045; SSF51045; 2.
DR SUPFAM; SSF81698; SSF81698; 5.
DR PROSITE; PS51676; FF; 6.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..724
FT /note="WW domain-containing protein ZK1098.1"
FT /id="PRO_0000076098"
FT DOMAIN 78..111
FT /note="WW 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 123..156
FT /note="WW 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 224..282
FT /note="FF 1"
FT DOMAIN 295..349
FT /note="FF 2"
FT DOMAIN 353..422
FT /note="FF 3"
FT DOMAIN 442..502
FT /note="FF 4"
FT DOMAIN 507..562
FT /note="FF 5"
FT DOMAIN 578..632
FT /note="FF 6"
FT REGION 626..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..724
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..311
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_043943"
SQ SEQUENCE 724 AA; 84665 MW; BCC7AACAD5AA4C20 CRC64;
MLPNGFSFLN PNLVAAANIQ QVLLNQRFGM PPVGSIAQVP LLQMPTHSVV APHVAAPTRP
SPMLVPPGMG IDESHSSPSV ESDWSVHTNE KGTPYYHNRV TKQTSWIKPD VLKTPLERST
SGQPQQGQWK EFMSDDGKPY YYNTLTKKTQ WVKPDGEEIT KGEQKPAAKA ATVDTVALAA
AVQQKKAESD LDKAMKATLA SMPNVPLPSE KKEEESVNDE VELKKRQSER FRELLRDKYN
DGKITTNCNW DQAVKWIQND PRFRILNKVS EKKQLFNAWK VQRGKEERDE KRLAIKKSKE
DLEKFLQEHP KMKESLKYQK ASDIFSKEPL WIAVNDEDRK EIFRDCIDFV ARRDKEKKEE
DRKRDIAAFS HVLQSMEQIT YKTTWAQAQR ILYENPQFAE RKDLHFMDKE DALTVFEDHI
KQAEKEHDEE KEQEEKRLRR QQRKVREEYR LLLESLHKRG ELTSMSLWTS LFPIISTDTR
FELMLFQPGS SPLDLFKFFV EDLKEQYTED RRLIKEILTE KGCQVIATTE YREFSDWVVS
HEKGGKVDHG NMKLCYNSLI EKAESKAKDE EKESLRRKRR LESEFRNLLK EHNVDKDSEW
TVIKPKIEKD KAYLAMENDD ERETAFNHYK NGTSGTTAGS EILEKKKKKK DKKKKNKRSD
NNSESEGEIR EKEKKKKKKH SKEDRMDDEE RGKKSKKSRK RSPSRSESPR HSSEKRKRRE
SEAD
