ID   YOAE_ECOL6              Reviewed;         518 AA.
AC   P0AEC1; P76262;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=UPF0053 inner membrane protein YoaE;
GN   Name=yoaE; OrderedLocusNames=c2222;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN80681.1; -; Genomic_DNA.
DR   RefSeq; WP_000394983.1; NC_004431.1.
DR   AlphaFoldDB; P0AEC1; -.
DR   SMR; P0AEC1; -.
DR   STRING; 199310.c2222; -.
DR   EnsemblBacteria; AAN80681; AAN80681; c2222.
DR   GeneID; 66674295; -.
DR   KEGG; ecc:c2222; -.
DR   eggNOG; COG1253; Bacteria.
DR   HOGENOM; CLU_015237_0_0_6; -.
DR   OMA; MRFINRH; -.
DR   BioCyc; ECOL199310:C2222-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR005496; Integral_membrane_TerC.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   Pfam; PF03741; TerC; 1.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; SSF54631; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain; Cell inner membrane; Cell membrane; Membrane; Repeat;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..518
FT                   /note="UPF0053 inner membrane protein YoaE"
FT                   /id="PRO_0000088361"
FT   TOPO_DOM        1..13
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        35..48
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..78
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..124
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..184
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        228..354
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        376..518
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          304..363
FT                   /note="CBS 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT   DOMAIN          367..427
FT                   /note="CBS 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ   SEQUENCE   518 AA;  56528 MW;  90DF7C9A092F1ECC CRC64;
     MEFLMDPSIW AGLLTLVVLE IVLGIDNLVF IAILADKLPP KQRDKARLLG LSLALIMRLG
     LLSLISWMVT LTKPLFTVMD FSFSGRDLIM LFGGIFLLFK ATTELHERLE NRDHDSGHGK
     GYASFWVVVT QIVILDAVFS LDAVITAVGM VNHLPVMMAA VVIAMAVMLL ASKPLTRFVN
     QHPTVVVLCL SFLLMIGLSL VAEGFGFHIP KGYLYAAIGF SIIIEVFNQI ARRNFIRHQS
     TLPLRARTAD AILRLMGGKR QANVQHDADN PMPMPIPEGA FAEEERYMIN GVLTLASRSL
     RGIMTPRGEI SWVDANLGVD EIREQLLSSP HSLFPVCRGE LDEIIGIVRA KELLVALEEG
     VDVAAIASAS PAIIVPETLD PINLLGVLRR ARGSFVIVTN EFGVVQGLVT PLDVLEAIAG
     EFPDADETPE IITDGDGWLV KGGTDLHALQ QALDVEHLAD DDDIATVAGL VISANGHIPR
     VGDVIDVGPL HITIIEANDY RVDLVRIVKE QPAHDEDE