YOAE_ECOLI
ID YOAE_ECOLI Reviewed; 518 AA.
AC P0AEC0; P76262;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=UPF0053 inner membrane protein YoaE;
GN Name=yoaE; OrderedLocusNames=b1816, JW1805;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the UPF0053 family. {ECO:0000305}.
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DR EMBL; U00096; AAC74886.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA15623.1; -; Genomic_DNA.
DR PIR; H64942; H64942.
DR RefSeq; NP_416330.1; NC_000913.3.
DR RefSeq; WP_000394983.1; NZ_STEB01000009.1.
DR AlphaFoldDB; P0AEC0; -.
DR SMR; P0AEC0; -.
DR BioGRID; 4260347; 14.
DR BioGRID; 850692; 1.
DR IntAct; P0AEC0; 1.
DR STRING; 511145.b1816; -.
DR jPOST; P0AEC0; -.
DR PaxDb; P0AEC0; -.
DR PRIDE; P0AEC0; -.
DR EnsemblBacteria; AAC74886; AAC74886; b1816.
DR EnsemblBacteria; BAA15623; BAA15623; BAA15623.
DR GeneID; 66674295; -.
DR GeneID; 946335; -.
DR KEGG; ecj:JW1805; -.
DR KEGG; eco:b1816; -.
DR PATRIC; fig|511145.12.peg.1893; -.
DR EchoBASE; EB3290; -.
DR eggNOG; COG1253; Bacteria.
DR HOGENOM; CLU_015237_0_0_6; -.
DR InParanoid; P0AEC0; -.
DR OMA; MRFINRH; -.
DR PhylomeDB; P0AEC0; -.
DR BioCyc; EcoCyc:G6997-MON; -.
DR PRO; PR:P0AEC0; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.10.580.10; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR005496; Integral_membrane_TerC.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR Pfam; PF03471; CorC_HlyC; 1.
DR Pfam; PF03741; TerC; 1.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; SSF54631; 1.
DR SUPFAM; SSF56176; SSF56176; 1.
DR PROSITE; PS51371; CBS; 2.
PE 1: Evidence at protein level;
KW CBS domain; Cell inner membrane; Cell membrane; Membrane;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..518
FT /note="UPF0053 inner membrane protein YoaE"
FT /id="PRO_0000088359"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..48
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..124
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 171..184
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..354
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 376..518
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 304..363
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 367..427
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
SQ SEQUENCE 518 AA; 56528 MW; 90DF7C9A092F1ECC CRC64;
MEFLMDPSIW AGLLTLVVLE IVLGIDNLVF IAILADKLPP KQRDKARLLG LSLALIMRLG
LLSLISWMVT LTKPLFTVMD FSFSGRDLIM LFGGIFLLFK ATTELHERLE NRDHDSGHGK
GYASFWVVVT QIVILDAVFS LDAVITAVGM VNHLPVMMAA VVIAMAVMLL ASKPLTRFVN
QHPTVVVLCL SFLLMIGLSL VAEGFGFHIP KGYLYAAIGF SIIIEVFNQI ARRNFIRHQS
TLPLRARTAD AILRLMGGKR QANVQHDADN PMPMPIPEGA FAEEERYMIN GVLTLASRSL
RGIMTPRGEI SWVDANLGVD EIREQLLSSP HSLFPVCRGE LDEIIGIVRA KELLVALEEG
VDVAAIASAS PAIIVPETLD PINLLGVLRR ARGSFVIVTN EFGVVQGLVT PLDVLEAIAG
EFPDADETPE IITDGDGWLV KGGTDLHALQ QALDVEHLAD DDDIATVAGL VISANGHIPR
VGDVIDVGPL HITIIEANDY RVDLVRIVKE QPAHDEDE
