ID   YOB_ANOGA               Reviewed;          56 AA.
AC   P0DP77;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2017, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Male determiner protein Yob {ECO:0000303|PubMed:27365445};
GN   Name=Yob {ECO:0000303|PubMed:27365445};
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DISRUPTION PHENOTYPE, AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=27365445; DOI=10.1126/science.aaf5605;
RA   Krzywinska E., Dennison N.J., Lycett G.J., Krzywinski J.;
RT   "A maleness gene in the malaria mosquito Anopheles gambiae.";
RL   Science 353:67-69(2016).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
CC   -!- FUNCTION: Male determiner protein (M-factor) that controls male somatic
CC       sexual differentiation. Acts as a dominant factor that regulates the
CC       mRNA splicing of doublesex (dsx) transcripts and promotes expression of
CC       male splice forms of dsx. {ECO:0000269|PubMed:27365445}.
CC   -!- DEVELOPMENTAL STAGE: Expression is male-specific. Transcription begins
CC       in embryos between 2 and 2.5 hours after oviposition, before blastoderm
CC       formation, and expression and continues throughout the life of the
CC       mosquito. Expression precedes establishment of sex-specific splicing of
CC       dsx by up to 6 hours. {ECO:0000269|PubMed:27365445}.
CC   -!- DISRUPTION PHENOTYPE: Male-specific lethality in embryos.
CC       {ECO:0000269|PubMed:27365445}.
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DR   EMBL; AAAB01008227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0DP77; -.
DR   SMR; P0DP77; -.
DR   VEuPathDB; VectorBase:AGAP029221; -.
DR   Proteomes; UP000007062; Unassembled WGS sequence.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030238; P:male sex determination; IDA:UniProtKB.
DR   GO; GO:0046661; P:male sex differentiation; IDA:UniProtKB.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0048024; P:regulation of mRNA splicing, via spliceosome; IDA:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Differentiation; mRNA processing; mRNA splicing; Reference proteome;
KW   Sexual differentiation.
FT   CHAIN           1..56
FT                   /note="Male determiner protein Yob"
FT                   /id="PRO_0000441318"
SQ   SEQUENCE   56 AA;  6281 MW;  8FFA1CF177C01098 CRC64;
     MFSQSACVQV HIKTNELHTA VVEKVILAMI SSCRTDNNQA LHKLLHVAVC EENYNV