YOCE_SCHPO
ID YOCE_SCHPO Reviewed; 674 AA.
AC O74400;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Uncharacterized RNA-binding protein C4F6.14;
GN ORFNames=SPBC4F6.14;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223; SER-225; SER-242 AND
RP SER-247, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329671; CAA20734.1; -; Genomic_DNA.
DR PIR; T40511; T40511.
DR RefSeq; NP_596114.1; NM_001022031.2.
DR AlphaFoldDB; O74400; -.
DR BioGRID; 277388; 7.
DR STRING; 4896.SPBC4F6.14.1; -.
DR iPTMnet; O74400; -.
DR MaxQB; O74400; -.
DR PaxDb; O74400; -.
DR PRIDE; O74400; -.
DR EnsemblFungi; SPBC4F6.14.1; SPBC4F6.14.1:pep; SPBC4F6.14.
DR GeneID; 2540871; -.
DR KEGG; spo:SPBC4F6.14; -.
DR PomBase; SPBC4F6.14; -.
DR VEuPathDB; FungiDB:SPBC4F6.14; -.
DR eggNOG; KOG0127; Eukaryota.
DR HOGENOM; CLU_011608_3_0_1; -.
DR InParanoid; O74400; -.
DR OMA; RNLPWSV; -.
DR PhylomeDB; O74400; -.
DR PRO; PR:O74400; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; NAS:PomBase.
DR GO; GO:0048255; P:mRNA stabilization; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:PomBase.
DR CDD; cd12674; RRM1_Nop4p; 1.
DR CDD; cd12675; RRM2_Nop4p; 1.
DR CDD; cd12677; RRM4_Nop4p; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR034805; Nop4_RRM1.
DR InterPro; IPR034806; Nop4_RRM2.
DR InterPro; IPR034809; Nop4_RRM4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00360; RRM; 4.
DR SMART; SM00361; RRM_1; 2.
DR SUPFAM; SSF54928; SSF54928; 4.
DR PROSITE; PS50102; RRM; 4.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..674
FT /note="Uncharacterized RNA-binding protein C4F6.14"
FT /id="PRO_0000310817"
FT DOMAIN 5..83
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 107..185
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 277..386
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 486..579
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 194..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 223
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 225
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 242
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 247
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 674 AA; 77034 MW; 7C08D543F0FC2CDD CRC64;
MNSNSTLFVR NLAFQTKQDD LTNFFSDVGP IKHAVVVTNP ETGENRGYGF VTFSMLEDAQ
RAAKELKNKK LHGRILRLDF ATPRKRSEVD TDQNKAVKKT IRQDNRPRLI IRNLPWSIKK
PQHLEPHFSK FGKVREIKIP TKGGGRMCGF AFVWMKDRKA AEEAMNSLNG TEIDGRPIAV
DWAVSKDAFE ATTLKDASSE EENKEFVSDE GHSIVTEDAS ADSESEEEVD GHSEGKELAG
ESEEEGSNVD DVEDSGDSSS DKNSINHEIR DNEGLEDTVF VRNLLFECTE QELYNHFRQF
GPLAYAKLVK DPATDRSLGR GFIKFRYEKD CQNCLEMASQ LPTQEPTEAE KRFLPSVLVD
EGIDTDSVSS RFLLHGRLLK VTSAVTRKEA SDINQKSLQE RKQKMGKGVD RRHLFLLNEG
KIAADHPLFN SLSETDKTLR SQSIAQRKKL LEKNPTLHLS LNRLSIRNIS RHIDPKILAM
LGRQAIRGFM DDVSKGLRAN ITEEEENLDK GHRLKRGKSG GVLKQAKVET EKAGAGRSKG
FGFMQFISHK YALMALRWLN GREITVKKII DAEIEWARKH KIPEPQLPNI DYNDRPRRLI
VEFAIENIQV VKRRQEKEKS FRQKAKQLKQ QEDEDNLKRK RSESDVEDNE AKEKQAKVAR
IIQRKRMKRR SRKN
