ID   YODQ_BACSU              Reviewed;         436 AA.
AC   O34984; Q796B3; Q7BVV8;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Uncharacterized metallohydrolase YodQ;
DE            EC=3.-.-.-;
GN   Name=yodQ; Synonyms=argE, yokP; OrderedLocusNames=BSU19710;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9734814; DOI=10.1093/dnares/5.3.195;
RA   Ghim S.-Y., Choi S.-K., Shin B.-S., Jeong Y.-M., Sorokin A., Ehrlich S.D.,
RA   Park S.-H.;
RT   "Sequence analysis of the Bacillus subtilis 168 chromosome region between
RT   the sspC and odhA loci (184 degrees-180 degrees).";
RL   DNA Res. 5:195-201(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) or Co(2+) ions per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the peptidase M20A family. {ECO:0000305}.
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DR   EMBL; AF006665; AAB81157.1; -; Genomic_DNA.
DR   EMBL; AF015775; AAB72071.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB13862.1; -; Genomic_DNA.
DR   PIR; H69588; H69588.
DR   RefSeq; NP_389852.1; NC_000964.3.
DR   RefSeq; WP_010886532.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O34984; -.
DR   SMR; O34984; -.
DR   STRING; 224308.BSU19710; -.
DR   MEROPS; M20.A21; -.
DR   PaxDb; O34984; -.
DR   PRIDE; O34984; -.
DR   DNASU; 940044; -.
DR   EnsemblBacteria; CAB13862; CAB13862; BSU_19710.
DR   GeneID; 940044; -.
DR   KEGG; bsu:BSU19710; -.
DR   PATRIC; fig|224308.43.peg.2091; -.
DR   eggNOG; COG0624; Bacteria.
DR   InParanoid; O34984; -.
DR   OMA; CAHQPGE; -.
DR   PhylomeDB; O34984; -.
DR   BioCyc; BSUB:BSU19710-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd03895; M20_ArgE_DapE-like; 1.
DR   InterPro; IPR010182; ArgE/DapE.
DR   InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR   InterPro; IPR002933; Peptidase_M20.
DR   InterPro; IPR011650; Peptidase_M20_dimer.
DR   InterPro; IPR033687; YodQ-like.
DR   Pfam; PF07687; M20_dimer; 1.
DR   Pfam; PF01546; Peptidase_M20; 1.
DR   SUPFAM; SSF55031; SSF55031; 1.
DR   TIGRFAMs; TIGR01910; DapE-ArgE; 1.
PE   3: Inferred from homology;
KW   Cobalt; Hydrolase; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..436
FT                   /note="Uncharacterized metallohydrolase YodQ"
FT                   /id="PRO_0000386550"
FT   ACT_SITE        105
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        170
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   BINDING         103
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         136
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         136
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         171
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         194
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         394
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   436 AA;  48555 MW;  5E60E80AD6777BDD CRC64;
     MRMQDIERKV IEWLDQHSAK AIRLLKRLIG EKSTLGSEFN AQAVVLEKLR QFHMDIDVWE
     PSIKQLKQHP YFKSNRSDFH ESPNIVAKKT GAGGGRSLIL NGHIDVVPEG SVKDWKYEPY
     QAVEENGKIY GRGSTDMKGG NTALLFALEA LHACDVKLKG DVLFQSVVDE ECGGAGTLSA
     IMRGYRADGA LIPEPTNMKL FIKQQGSMWF RITVKGLSAH GGTRYEGVSA IEKSMHVITA
     IQELEKVRNA RISDPLYDNI PIPVPVNIGT ISGGAWPSSV ADRVVIEGRC GIAPHEKPEA
     VKLELENWLK DLEYHDEWFK RHPVQVEWFG AQWLPNDLPD DHPLISVLQS AYQKMKQTEP
     IIEASPWGTD GGLLYHAGDT PVIVFGPGET KTAHQANEYI EVEAMIESAK IIALFVMDWC
     GLHTDGEDAD AQVNKE