ID   YOEB_MYCBO              Reviewed;          85 AA.
AC   P64529; A0A1R3Y3Z8; O50387; X2BNR1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Toxin YoeB;
DE            EC=3.1.-.-;
DE   AltName: Full=Endoribonuclease YoeB;
DE   AltName: Full=Putative mRNA interferase YoeB;
GN   Name=yoeB; OrderedLocusNames=BQ2027_MB3393;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Has
CC       RNase activity and preferentially cleaves at the 3'-end of purine
CC       ribonucleotides (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a toxin-antitoxin complex with YefM in which the toxin
CC       is probably inactive. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YoeB family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU02022.1; -; Genomic_DNA.
DR   RefSeq; NP_857034.1; NC_002945.3.
DR   RefSeq; WP_003417760.1; NC_002945.4.
DR   AlphaFoldDB; P64529; -.
DR   SMR; P64529; -.
DR   EnsemblBacteria; SIU02022; SIU02022; BQ2027_MB3393.
DR   GeneID; 45427357; -.
DR   PATRIC; fig|233413.5.peg.3728; -.
DR   OMA; KCRFHYD; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   InterPro; IPR009614; YoeB_toxin.
DR   PANTHER; PTHR38039; PTHR38039; 1.
DR   Pfam; PF06769; YoeB_toxin; 1.
DR   SUPFAM; SSF143011; SSF143011; 1.
DR   TIGRFAMs; TIGR02116; toxin_Txe_YoeB; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Toxin-antitoxin system.
FT   CHAIN           1..85
FT                   /note="Toxin YoeB"
FT                   /id="PRO_0000216212"
FT   ACT_SITE        47
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        84
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   85 AA;  10102 MW;  8663A289B5FD9DAF CRC64;
     MRSVNFDPDA WEDFLFWLAA DRKTARRITR LIGEIQRDPF SGIGKPEPLQ GELSGYWSRR
     IDDEHRLVYR AGDDEVTMLK ARYHY