ID   YOEB_STRCO              Reviewed;          84 AA.
AC   Q9Z4V8;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Toxin YoeB;
DE            EC=3.1.-.-;
DE   AltName: Full=Endoribonuclease YoeB;
DE   AltName: Full=Putative mRNA interferase YoeB;
GN   Name=yoeB; OrderedLocusNames=SCO2236; ORFNames=SCBAC17D6.03;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=10517584; DOI=10.1099/00221287-145-9-2313;
RA   Fink D., Falke D., Wohlleben W., Engels A.;
RT   "Nitrogen metabolism in Streptomyces coelicolor A3(2): modification of
RT   glutamine synthetase I by an adenylyltransferase.";
RL   Microbiology 145:2313-2322(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Has
CC       RNase activity and preferentially cleaves at the 3'-end of purine
CC       ribonucleotides (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with YefM which inhibits its toxin activity.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YoeB family. {ECO:0000305}.
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DR   EMBL; Y17736; CAB38326.1; -; Genomic_DNA.
DR   EMBL; AL939111; CAC37262.1; -; Genomic_DNA.
DR   PIR; T51757; T51757.
DR   RefSeq; NP_626486.1; NC_003888.3.
DR   RefSeq; WP_003976577.1; NZ_VNID01000001.1.
DR   AlphaFoldDB; Q9Z4V8; -.
DR   SMR; Q9Z4V8; -.
DR   STRING; 100226.SCO2236; -.
DR   PRIDE; Q9Z4V8; -.
DR   GeneID; 1097669; -.
DR   KEGG; sco:SCO2236; -.
DR   PATRIC; fig|100226.15.peg.2274; -.
DR   eggNOG; COG4115; Bacteria.
DR   HOGENOM; CLU_169492_2_2_11; -.
DR   InParanoid; Q9Z4V8; -.
DR   OMA; KCRFHYD; -.
DR   PhylomeDB; Q9Z4V8; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016892; F:endoribonuclease activity, producing 3'-phosphomonoesters; IBA:GO_Central.
DR   GO; GO:0043024; F:ribosomal small subunit binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1903507; P:negative regulation of nucleic acid-templated transcription; IBA:GO_Central.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IBA:GO_Central.
DR   GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   InterPro; IPR009614; YoeB_toxin.
DR   PANTHER; PTHR38039; PTHR38039; 1.
DR   Pfam; PF06769; YoeB_toxin; 1.
DR   SUPFAM; SSF143011; SSF143011; 1.
DR   TIGRFAMs; TIGR02116; toxin_Txe_YoeB; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding;
KW   Toxin-antitoxin system.
FT   CHAIN           1..84
FT                   /note="Toxin YoeB"
FT                   /id="PRO_0000404327"
FT   ACT_SITE        46
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        83
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   84 AA;  9986 MW;  6AD38B9AA0158871 CRC64;
     MRITFTSHGW EDYVHWAESD RKVTKRINRL IADIARDPFK GVGKPEPLKG DLSGYWSRRI
     DDTHRLVYKP TDDQLVIVQA RYHY