ID   YOEB_SYNY3              Reviewed;          86 AA.
AC   P0CJ64;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Toxin YoeB;
DE            EC=3.1.-.-;
DE   AltName: Full=Endoribonuclease YoeB;
DE   AltName: Full=Putative mRNA interferase YoeB;
GN   Name=yoeB; OrderedLocusNames=ssr2754.1;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA   Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA   Sugiura M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region
RT   from map positions 64% to 92% of the genome.";
RL   DNA Res. 2:153-166(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. Has
CC       RNase activity and preferentially cleaves at the 3'-end of purine
CC       ribonucleotides (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with YefM which inhibits its toxin activity.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the YoeB family. {ECO:0000305}.
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DR   EMBL; BA000022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P0CJ64; -.
DR   SMR; P0CJ64; -.
DR   InParanoid; P0CJ64; -.
DR   PhylomeDB; P0CJ64; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0016892; F:endoribonuclease activity, producing 3'-phosphomonoesters; IBA:GO_Central.
DR   GO; GO:0043024; F:ribosomal small subunit binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1903507; P:negative regulation of nucleic acid-templated transcription; IBA:GO_Central.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IBA:GO_Central.
DR   GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR   Gene3D; 3.30.2310.20; -; 1.
DR   InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR   InterPro; IPR009614; YoeB_toxin.
DR   PANTHER; PTHR38039; PTHR38039; 1.
DR   Pfam; PF06769; YoeB_toxin; 1.
DR   SUPFAM; SSF143011; SSF143011; 1.
DR   TIGRFAMs; TIGR02116; toxin_Txe_YoeB; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding;
KW   Toxin-antitoxin system.
FT   CHAIN           1..86
FT                   /note="Toxin YoeB"
FT                   /id="PRO_0000404328"
FT   ACT_SITE        46
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        83
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   86 AA;  10347 MW;  25B32CBF9B97575C CRC64;
     MKIAFTELSW HDYLWFQQND KKLLKRINLL IKAIARDPFD GIGKPEPLKA NLSGYWSRRI
     NSEHRLVYTI ADRDLLIISC RFHYQR