ID   YOF5_CAEEL              Reviewed;         321 AA.
AC   Q09632;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 3.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Uncharacterized oxidoreductase ZK1290.5;
DE            EC=1.-.-.-;
GN   ORFNames=ZK1290.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. {ECO:0000305}.
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DR   EMBL; FO080700; CCD65936.1; -; Genomic_DNA.
DR   PIR; T34503; T34503.
DR   RefSeq; NP_495578.2; NM_063177.2.
DR   AlphaFoldDB; Q09632; -.
DR   SMR; Q09632; -.
DR   STRING; 6239.ZK1290.5; -.
DR   PaxDb; Q09632; -.
DR   EnsemblMetazoa; ZK1290.5.1; ZK1290.5.1; WBGene00022887.
DR   GeneID; 191555; -.
DR   KEGG; cel:CELE_ZK1290.5; -.
DR   UCSC; ZK1290.5; c. elegans.
DR   CTD; 191555; -.
DR   WormBase; ZK1290.5; CE36068; WBGene00022887; -.
DR   eggNOG; KOG1577; Eukaryota.
DR   GeneTree; ENSGT00940000164809; -.
DR   HOGENOM; CLU_023205_0_1_1; -.
DR   InParanoid; Q09632; -.
DR   OMA; KLWPTDQ; -.
DR   OrthoDB; 1216642at2759; -.
DR   PhylomeDB; Q09632; -.
DR   PRO; PR:Q09632; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00022887; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IBA:GO_Central.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..321
FT                   /note="Uncharacterized oxidoreductase ZK1290.5"
FT                   /id="PRO_0000124681"
FT   ACT_SITE        49
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         106
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   SITE            74
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   321 AA;  36709 MW;  43AD97E64F899A2B CRC64;
     MIPTTVLSNN VEMPLIGLGT THSGGYYHDA VLHSIKKCGY RLIDTAKRYG VEKQLGIAVK
     NCSVPREEMF LSTKLWPVDC GDEVYNAFQT SCEKLQTDYL DMYMIHMPQL PDWIVNQKET
     KEKTWRQMEL LYEDEHVRSI GVSNYSIEDL DELLEFASIL PHANQVELHP WFHQADLKNY
     CDELGILTMG YCPLAKGKYL EDETLCKIAS KYQKSPAQIC LRWSIQQNVP TVPKSTDCRR
     LKENTNVFDF ELSAEDMNTL NSFSSQNRKI VDLSNICQKM SLPDGYKLNG RVFGVPEEDE
     TIPKSCSKCA QKQNVPLPVC I