ID   YOFA_BACSU              Reviewed;         285 AA.
AC   O34685;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=HTH-type transcriptional regulator YofA;
GN   Name=yofA; OrderedLocusNames=BSU18420;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [2]
RP   FUNCTION IN CELL DIVISION, AND INDUCTION.
RC   STRAIN=168;
RX   PubMed=17526699; DOI=10.1128/jb.00467-07;
RA   Lu Z., Takeuchi M., Sato T.;
RT   "The LysR-type transcriptional regulator YofA controls cell division
RT   through the regulation of expression of ftsW in Bacillus subtilis.";
RL   J. Bacteriol. 189:5642-5651(2007).
CC   -!- FUNCTION: Regulates expression of the cell division protein ftsW, and
CC       is essential for cell viability during stationary phase.
CC       {ECO:0000269|PubMed:17526699}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Maximally expressed at stationary phase.
CC       {ECO:0000269|PubMed:17526699}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AL009126; CAB13725.1; -; Genomic_DNA.
DR   PIR; E69905; E69905.
DR   RefSeq; NP_389724.1; NC_000964.3.
DR   RefSeq; WP_003231468.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O34685; -.
DR   SMR; O34685; -.
DR   STRING; 224308.BSU18420; -.
DR   PaxDb; O34685; -.
DR   PRIDE; O34685; -.
DR   DNASU; 940018; -.
DR   EnsemblBacteria; CAB13725; CAB13725; BSU_18420.
DR   GeneID; 940018; -.
DR   KEGG; bsu:BSU18420; -.
DR   PATRIC; fig|224308.179.peg.2009; -.
DR   eggNOG; COG0583; Bacteria.
DR   InParanoid; O34685; -.
DR   OMA; VYGPVEH; -.
DR   PhylomeDB; O34685; -.
DR   BioCyc; BSUB:BSU18420-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cytoplasm; DNA-binding; Reference proteome;
KW   Septation; Transcription; Transcription regulation.
FT   CHAIN           1..285
FT                   /note="HTH-type transcriptional regulator YofA"
FT                   /id="PRO_0000105818"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   285 AA;  32051 MW;  BB2E4E5D25673F73 CRC64;
     MESGDLKIFQ AVAREGSITK AAQMLNYVQS NVTARVHNLE EDLNIRLFHR TNRGMKLTAA
     GENLLQYADQ VLSLLDQAEK STRMSRQPKG PLRIGSLETM AVTHLPEHAA SFLRRFPEVD
     LSVNTADTHH LIQQVLDHKV DGAFVYGPVE HAAVRQLHVS HDELVLISSR EGTAEDMLQQ
     PMLFFGAGCS HRDRVKRLLE EAGIHNQKII EFGTLEAIIK GVSAGMGTAL LPKSAVDGSE
     HRTNVWIHQL PPSYQDLEIV FIYRKDFFIT SAFQTFLDEI NEMKR