ID   YOGA_LEPMJ              Reviewed;         358 AA.
AC   E5AE42;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Zinc-type alcohol dehydrogenase-like protein YogA {ECO:0000303|PubMed:23396262};
DE            EC=1.-.-.- {ECO:0000305|PubMed:23396262};
DE   AltName: Full=Phomenoic acid biosynthesis cluster protein YogA {ECO:0000303|PubMed:23396262};
GN   Name=Yog1 {ECO:0000303|PubMed:23396262}; ORFNames=LEMA_P002680;
OS   Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)
OS   (Blackleg fungus) (Phoma lingam).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC   Leptosphaeria; Leptosphaeria maculans species complex.
OX   NCBI_TaxID=985895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8;
RX   PubMed=21326234; DOI=10.1038/ncomms1189;
RA   Rouxel T., Grandaubert J., Hane J.K., Hoede C., van de Wouw A.P.,
RA   Couloux A., Dominguez V., Anthouard V., Bally P., Bourras S.,
RA   Cozijnsen A.J., Ciuffetti L.M., Degrave A., Dilmaghani A., Duret L.,
RA   Fudal I., Goodwin S.B., Gout L., Glaser N., Linglin J., Kema G.H.J.,
RA   Lapalu N., Lawrence C.B., May K., Meyer M., Ollivier B., Poulain J.,
RA   Schoch C.L., Simon A., Spatafora J.W., Stachowiak A., Turgeon B.G.,
RA   Tyler B.M., Vincent D., Weissenbach J., Amselem J., Quesneville H.,
RA   Oliver R.P., Wincker P., Balesdent M.-H., Howlett B.J.;
RT   "Effector diversification within compartments of the Leptosphaeria maculans
RT   genome affected by Repeat-Induced Point mutations.";
RL   Nat. Commun. 2:202-202(2011).
RN   [2]
RP   IDENTIFICATION, FUNCTION, INDUCTION, AND PATHWAY.
RX   PubMed=23396262; DOI=10.1016/j.fgb.2013.01.008;
RA   Elliott C.E., Callahan D.L., Schwenk D., Nett M., Hoffmeister D.,
RA   Howlett B.J.;
RT   "A gene cluster responsible for biosynthesis of phomenoic acid in the plant
RT   pathogenic fungus, Leptosphaeria maculans.";
RL   Fungal Genet. Biol. 53:50-58(2013).
CC   -!- FUNCTION: Zinc-type alcohol dehydrogenase-like protein; part of the
CC       gene cluster that mediates the biosynthesis of phomenoic acid, a long
CC       chain aliphatic carboxylic acid that does not appear to be essential
CC       for pathogenicity but may play a role in allowing to outcompete other
CC       fungi in the environmental niche via its antifungal properties
CC       (PubMed:23396262). The polyketide synthase produces the long methylated
CC       aliphatic carboxylic acid chain of phomenoic acid (Probable). The
CC       cluster-specific cytochrome P450 monooxygenase may then hydroxylate the
CC       methyl group of carbon 31 (Probable). The putative dehydrogenase YogA,
CC       which has no obvious role in phomenoic acid biosynthesis, may further
CC       modify phomenoic acid to produce a compound not identified yet
CC       (Probable). {ECO:0000269|PubMed:23396262, ECO:0000305|PubMed:23396262}.
CC   -!- PATHWAY: Secondary metabolite biosynthesis.
CC       {ECO:0000305|PubMed:23396262}.
CC   -!- INDUCTION: Expression is positively regulated by the phomenoic acid
CC       biosynthesis cluster-specific transcription regulator C6TF.
CC       {ECO:0000269|PubMed:23396262}.
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. Quinone oxidoreductase subfamily. {ECO:0000305}.
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DR   EMBL; FP929139; CBY01481.1; -; Genomic_DNA.
DR   RefSeq; XP_003844960.1; XM_003844912.1.
DR   AlphaFoldDB; E5AE42; -.
DR   SMR; E5AE42; -.
DR   STRING; 5022.CBY01481; -.
DR   EnsemblFungi; CBY01481; CBY01481; LEMA_P002680.1.
DR   GeneID; 13290522; -.
DR   eggNOG; KOG1198; Eukaryota.
DR   HOGENOM; CLU_026673_3_4_1; -.
DR   InParanoid; E5AE42; -.
DR   OMA; ACLPVAW; -.
DR   OrthoDB; 978190at2759; -.
DR   BRENDA; 1.1.5.5; 2984.
DR   Proteomes; UP000002668; Genome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..358
FT                   /note="Zinc-type alcohol dehydrogenase-like protein YogA"
FT                   /id="PRO_0000446534"
SQ   SEQUENCE   358 AA;  38409 MW;  8601DBC8D7AFF66A CRC64;
     MPFTLTLKPK KAKGGQVYYP LQLNVVSKPA PGPNEVLIQL EAAALNHRDF FLRQNLYPGL
     SFKSPMLSDG CGTVVELGPG CTTASNQLLG KKVILTPFRG WDSDPEGPED YSNFSTIGGV
     EPHFDLGMAQ NYISVHESEV ELLPEHLNHI EGAALPCCGI TAWRALVTKS GNAKPGRNIL
     VTGIGGGVAI QTLLFGVAMG CNMYVSSSSD EKLAKARELG AVGTVNYKTD SDSWDKTLGS
     LLPAERPYLD AVIDGAGGNI VTKALTVLKP GGVIVCYGMT VGPVMDWPMQ AALKNVDLRG
     TMVGSRAEFR EMVEFISTHK IKPVISRTVR GLDCVDAIDG LFEDIRTGKQ FGKLVIEI