YOHK_ECOLI
ID YOHK_ECOLI Reviewed; 231 AA.
AC P0AD19; P33373; Q2MAT7;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Inner membrane protein YohK;
GN Name=yohK; OrderedLocusNames=b2142, JW2130;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / BHB2600;
RA Richterich P., Lakey N., Gryan G., Jaehn L., Mintz L., Robison K.,
RA Church G.M.;
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 192-231.
RC STRAIN=K12;
RX PubMed=2575702; DOI=10.1111/j.1365-2958.1989.tb00120.x;
RA Valentin-Hansen P., Holst B., Josephsen J., Hammer K., Albrechtsen B.;
RT "CRP/cAMP- and CytR-regulated promoters in Escherichia coli K12: the cdd
RT promoter.";
RL Mol. Microbiol. 3:1385-1390(1989).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the YohK (E.coli)/YwbG (IPA-22R) (B.subtilis)
CC family. {ECO:0000305}.
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DR EMBL; U00007; AAA60505.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75203.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76619.1; -; Genomic_DNA.
DR EMBL; X16419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; E64982; E64982.
DR RefSeq; NP_416647.1; NC_000913.3.
DR RefSeq; WP_000968208.1; NZ_STEB01000002.1.
DR AlphaFoldDB; P0AD19; -.
DR BioGRID; 4260834; 16.
DR STRING; 511145.b2142; -.
DR PaxDb; P0AD19; -.
DR PRIDE; P0AD19; -.
DR EnsemblBacteria; AAC75203; AAC75203; b2142.
DR EnsemblBacteria; BAE76619; BAE76619; BAE76619.
DR GeneID; 67414574; -.
DR GeneID; 949125; -.
DR KEGG; ecj:JW2130; -.
DR KEGG; eco:b2142; -.
DR PATRIC; fig|1411691.4.peg.100; -.
DR EchoBASE; EB1959; -.
DR eggNOG; COG1346; Bacteria.
DR HOGENOM; CLU_082099_3_0_6; -.
DR InParanoid; P0AD19; -.
DR OMA; AQFVHFM; -.
DR PhylomeDB; P0AD19; -.
DR BioCyc; EcoCyc:EG12024-MON; -.
DR PRO; PR:P0AD19; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISM:EcoCyc.
DR InterPro; IPR005261; CHP00659.
DR InterPro; IPR007300; CidB/LrgB.
DR PANTHER; PTHR30249; PTHR30249; 1.
DR Pfam; PF04172; LrgB; 1.
DR TIGRFAMs; TIGR00659; TIGR00659; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..231
FT /note="Inner membrane protein YohK"
FT /id="PRO_0000169140"
FT TOPO_DOM 1
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..90
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..118
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..231
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 206..231
FT /note="LALVLCGIITSLIAPFLFPIILAVMG -> ASAGVMRDNYFADRTVPFPDYS
FT GSNGLKFAMRRAFLMYVSRVA (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 231 AA; 24470 MW; 178A705904384DD0 CRC64;
MMANIWWSLP LTLIVFFAAR KLAARYKFPL LNPLLVAMVV IIPFLMLTGI SYDSYFKGSE
VLNDLLQPAV VALAYPLYEQ LHQIRARWKS IITICFIGSV VAMVTGTSVA LLMGASPEIA
ASILPKSVTT PIAMAVGGSI GGIPAISAVC VIFVGILGAV FGHTLLNAMR IRTKAARGLA
MGTASHALGT ARCAELDYQE GAFSSLALVL CGIITSLIAP FLFPIILAVM G
