ID   YOI9_SCHPO              Reviewed;         414 AA.
AC   Q9Y7J5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=TBC domain-containing protein C1778.09;
GN   ORFNames=SPBC1778.09;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1] {ECO:0000312|EMBL:CAB39804.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
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DR   EMBL; CU329671; CAB39804.1; -; Genomic_DNA.
DR   PIR; T39691; T39691.
DR   RefSeq; NP_596292.1; NM_001022214.2.
DR   AlphaFoldDB; Q9Y7J5; -.
DR   SMR; Q9Y7J5; -.
DR   BioGRID; 276268; 35.
DR   STRING; 4896.SPBC1778.09.1; -.
DR   iPTMnet; Q9Y7J5; -.
DR   MaxQB; Q9Y7J5; -.
DR   PaxDb; Q9Y7J5; -.
DR   PRIDE; Q9Y7J5; -.
DR   EnsemblFungi; SPBC1778.09.1; SPBC1778.09.1:pep; SPBC1778.09.
DR   GeneID; 2539715; -.
DR   KEGG; spo:SPBC1778.09; -.
DR   PomBase; SPBC1778.09; -.
DR   VEuPathDB; FungiDB:SPBC1778.09; -.
DR   eggNOG; KOG1102; Eukaryota.
DR   HOGENOM; CLU_003663_0_0_1; -.
DR   InParanoid; Q9Y7J5; -.
DR   OMA; PMAFSIK; -.
DR   PhylomeDB; Q9Y7J5; -.
DR   Reactome; R-SPO-6798695; Neutrophil degranulation.
DR   Reactome; R-SPO-8854214; TBC/RABGAPs.
DR   PRO; PR:Q9Y7J5; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005096; F:GTPase activator activity; ISM:PomBase.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; NAS:PomBase.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   4: Predicted;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..414
FT                   /note="TBC domain-containing protein C1778.09"
FT                   /id="PRO_0000312840"
FT   DOMAIN          158..343
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ   SEQUENCE   414 AA;  47702 MW;  B0A541F09E06554C CRC64;
     MENPSPTRTT NLQRIRSLYR LQEDKNNLNI PEPINGKVQE IDTKESLENV DRYGNYRSDF
     NVNNLGFYKV SKDPTLDKPN PAKRLGNKLI GHDDMLKYVD ESIFMVVPGE SHDRNEISAK
     ELSRIQKWKS MCSIHLVSGN QLHSFRKTRK LILRTFKGIP DCWRSIAWWS FLVDSLPDKK
     LIDKYYQLNE QICDYDVQID LDVPRTAATH FLFRKRYIGG QRLLFRVLHA VALYIPRVGY
     VQGMASIAAT LLIYYPEEQA FIMMVNLLEN RGMGDLFSSG FDTLLKAFDM LKHELSFTQS
     GRHLAEIGAE PSAFATRWYL TVFHQCVPFH TQLRIWDLLF LLGGSKGQTV RLLQATSLAV
     IQGMWDTLID ADFEVVMQAL SGVIPIQNDN ALLARIQLFW EKMPSENSSK SKRN