YOKD_BACSU
ID YOKD_BACSU Reviewed; 272 AA.
AC O32003;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=SPbeta prophage-derived aminoglycoside N(3')-acetyltransferase-like protein YokD;
DE EC=2.3.1.-;
GN Name=yokD; OrderedLocusNames=BSU21630;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH COENZYME A, AND
RP SUBUNIT.
RG New York structural genomix research consortium (NYSGXRC);
RT "Crystal structure of yokD protein from Bacillus subtilis.";
RL Submitted (FEB-2007) to the PDB data bank.
CC -!- FUNCTION: May contribute to antibiotic resistance. {ECO:0000305}.
CC -!- SUBUNIT: Homodimer. {ECO:0000305|Ref.2}.
CC -!- SIMILARITY: Belongs to the antibiotic N-acetyltransferase family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL009126; CAB14081.1; -; Genomic_DNA.
DR RefSeq; NP_390046.1; NC_000964.3.
DR RefSeq; WP_004399070.1; NZ_JNCM01000036.1.
DR PDB; 2NYG; X-ray; 2.60 A; A/B/C/D/E/F=2-272.
DR PDBsum; 2NYG; -.
DR AlphaFoldDB; O32003; -.
DR SMR; O32003; -.
DR STRING; 224308.BSU21630; -.
DR jPOST; O32003; -.
DR PaxDb; O32003; -.
DR PRIDE; O32003; -.
DR EnsemblBacteria; CAB14081; CAB14081; BSU_21630.
DR GeneID; 939106; -.
DR KEGG; bsu:BSU21630; -.
DR PATRIC; fig|224308.179.peg.2362; -.
DR eggNOG; COG2746; Bacteria.
DR InParanoid; O32003; -.
DR OMA; HATDCRL; -.
DR PhylomeDB; O32003; -.
DR BioCyc; BSUB:BSU21630-MON; -.
DR EvolutionaryTrace; O32003; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0046353; F:aminoglycoside 3-N-acetyltransferase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR InterPro; IPR003679; Amioglycoside_AcTrfase.
DR InterPro; IPR028345; Antibiotic_NAT-like.
DR PANTHER; PTHR11104; PTHR11104; 1.
DR Pfam; PF02522; Antibiotic_NAT; 1.
DR SUPFAM; SSF110710; SSF110710; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acyltransferase; Antibiotic resistance; Reference proteome;
KW Transferase.
FT CHAIN 1..272
FT /note="SPbeta prophage-derived aminoglycoside N(3')-
FT acetyltransferase-like protein YokD"
FT /id="PRO_0000360739"
FT BINDING 38..44
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT BINDING 113
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000269|Ref.2"
FT HELIX 2..6
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 14..24
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 31..36
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 39..41
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 47..59
FT /evidence="ECO:0007829|PDB:2NYG"
FT TURN 60..62
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 63..68
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 77..79
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 87..89
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 92..95
FT /evidence="ECO:0007829|PDB:2NYG"
FT TURN 102..104
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 109..111
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 113..118
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 130..132
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 134..138
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 141..145
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 150..152
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 159..165
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 169..174
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 177..179
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 182..186
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 189..191
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 195..200
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 211..216
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 220..222
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 223..233
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 237..241
FT /evidence="ECO:0007829|PDB:2NYG"
FT STRAND 244..250
FT /evidence="ECO:0007829|PDB:2NYG"
FT HELIX 251..267
FT /evidence="ECO:0007829|PDB:2NYG"
SQ SEQUENCE 272 AA; 30914 MW; 55AA48E971A3EE35 CRC64;
MKKIVESTTF PRTKQSITED LKALGLKKGM TVLVHSSLSS IGWVNGGAVA VIQALIDVVT
EEGTIVMPSQ SVELSDPKEW GNPPVPEEWW DIIRESMPAY NSNYTPTTRG MGQIVELFRS
YPEVKRSNHP NYSFVAWGKH KNKILNQHPL EFGLGEQSPL GKLYIRESYV LLLGADFDSS
TCFHLAEYRI PYQKIINRGA PIIVEGKRVW KEYKELEFRE ELFQEVGQAF EAEHNMKVGK
VGSANCRLFS LTEAVDFAEK WFINNDSKNI KK
