YOL19_YEAST
ID YOL19_YEAST Reviewed; 551 AA.
AC Q08157; D6W247;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Uncharacterized membrane protein YOL019W;
GN OrderedLocusNames=YOL019W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=15282802; DOI=10.1002/yea.1133;
RA Sundin B.A., Chiu C.-H., Riffle M., Davis T.N., Muller E.G.D.;
RT "Localization of proteins that are coordinately expressed with Cln2 during
RT the cell cycle.";
RL Yeast 21:793-800(2004).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-224; SER-232 AND SER-363, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein.
CC Cell membrane; Multi-pass membrane protein.
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DR EMBL; Z74761; CAA99018.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10763.1; -; Genomic_DNA.
DR PIR; S66701; S66701.
DR RefSeq; NP_014623.1; NM_001183273.1.
DR AlphaFoldDB; Q08157; -.
DR BioGRID; 34384; 70.
DR IntAct; Q08157; 1.
DR MINT; Q08157; -.
DR STRING; 4932.YOL019W; -.
DR iPTMnet; Q08157; -.
DR MaxQB; Q08157; -.
DR PaxDb; Q08157; -.
DR PRIDE; Q08157; -.
DR EnsemblFungi; YOL019W_mRNA; YOL019W; YOL019W.
DR GeneID; 854141; -.
DR KEGG; sce:YOL019W; -.
DR SGD; S000005379; YOL019W.
DR VEuPathDB; FungiDB:YOL019W; -.
DR eggNOG; ENOG502RYG1; Eukaryota.
DR HOGENOM; CLU_026237_0_0_1; -.
DR InParanoid; Q08157; -.
DR OMA; HKPFTEL; -.
DR BioCyc; YEAST:G3O-33435-MON; -.
DR PRO; PR:Q08157; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08157; protein.
DR GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0035838; C:growing cell tip; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:SGD.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR009571; SUR7/Rim9-like_fungi.
DR Pfam; PF06687; SUR7; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Vacuole.
FT CHAIN 1..551
FT /note="Uncharacterized membrane protein YOL019W"
FT /id="PRO_0000245272"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..88
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..160
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..551
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 280..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 224
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
FT MOD_RES 232
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
FT MOD_RES 363
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
SQ SEQUENCE 551 AA; 60901 MW; 1768390DEF97BA08 CRC64;
MKKNSSVVFF LVGLSQFVTM AFLIIGSITA PIFKQIGYSK YDEITYGTFG YCKEGSCSKA
SYNYHPDELS DSDSNWKLNS NARSILGKII FITPIAAGLN FLGFLCTIMS VLLINVLSSD
RVGSASAIMF FVNLTFSTLG FLSASLICIV VFLLFYPHVT WCSWVLIPGA ALSLLVIPLI
FSAYSRSSGS RDDDETEELE EKGMLLNDPY LSSKSGRFDI DADSEANLRG DSRTNLLGDN
FKNGTNITVV PDIISHNQDP KLSNITTSTT SDISTFDKEA KDMENSNGSG LNEEEDDGMA
YDKRRSTSTY SVIESESGLK NGSVSNNYVR NNGSNTSNNI NYKVPLGKTE ISSSASLASS
DYSQREVIPH RNPSRLLNDI METSFNEPND SHINSMSSYN DKDSTLTSIS QRGVNPEVYN
QMPRETAAGP ANIRPYAGQP HPAPLVYPQQ RLQPQQQQPQ QQYHQYNLYQ RTTPAGPDPS
NVILQSNPYF NVAPNQVPQH RNPVPGVGFA PNPLPNQSPI TQGYKPAYKR RMQNKNLPRA
TTSLNNPYGF R
