ID   CBPA_SALTY              Reviewed;         306 AA.
AC   P63263; O33916;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Curved DNA-binding protein {ECO:0000255|HAMAP-Rule:MF_01154};
GN   Name=cbpA {ECO:0000255|HAMAP-Rule:MF_01154}; OrderedLocusNames=STM1112;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-214.
RX   PubMed=9260936; DOI=10.1128/jb.179.16.4977-4984.1997;
RA   Gupta S.D., Wu H.C., Rick P.D.;
RT   "A Salmonella typhimurium genetic locus which confers copper tolerance on
RT   copper-sensitive mutants of Escherichia coli.";
RL   J. Bacteriol. 179:4977-4984(1997).
CC   -!- FUNCTION: DNA-binding protein that preferentially recognizes a curved
CC       DNA sequence. It is probably a functional analog of DnaJ; displays
CC       overlapping activities with DnaJ, but functions under different
CC       conditions, probably acting as a molecular chaperone in an adaptive
CC       response to environmental stresses other than heat shock. Lacks
CC       autonomous chaperone activity; binds native substrates and targets them
CC       for recognition by DnaK. Its activity is inhibited by the binding of
CC       CbpM. {ECO:0000255|HAMAP-Rule:MF_01154}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_01154}.
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DR   EMBL; AE006468; AAL20044.1; -; Genomic_DNA.
DR   EMBL; U75949; AAC45599.1; -; Genomic_DNA.
DR   RefSeq; NP_460085.1; NC_003197.2.
DR   RefSeq; WP_000420603.1; NC_003197.2.
DR   AlphaFoldDB; P63263; -.
DR   SMR; P63263; -.
DR   STRING; 99287.STM1112; -.
DR   PaxDb; P63263; -.
DR   EnsemblBacteria; AAL20044; AAL20044; STM1112.
DR   GeneID; 1252630; -.
DR   KEGG; stm:STM1112; -.
DR   PATRIC; fig|99287.12.peg.1177; -.
DR   HOGENOM; CLU_017633_0_0_6; -.
DR   OMA; WDAGFEF; -.
DR   PhylomeDB; P63263; -.
DR   BioCyc; SENT99287:STM1112-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003681; F:bent DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   HAMAP; MF_01154; CbpA; 1.
DR   InterPro; IPR023859; DNA-bd_curved-DNA.
DR   InterPro; IPR002939; DnaJ_C.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR008971; HSP40/DnaJ_pept-bd.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF01556; DnaJ_C; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   SUPFAM; SSF49493; SSF49493; 2.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; DNA-binding; Reference proteome.
FT   CHAIN           1..306
FT                   /note="Curved DNA-binding protein"
FT                   /id="PRO_0000169995"
FT   DOMAIN          5..69
FT                   /note="J"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01154"
FT   CONFLICT        211..214
FT                   /note="LEVV -> PQDG (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   306 AA;  34693 MW;  CE844989AD3162CE CRC64;
     MELKDYYAIM GVKPTDDLKT IKTAYRRLAR KYHPDVSKEP DAEARFKEVA EAWEVLSDEQ
     RRAEYDQLWQ HRNDPQFNRQ FQQHEGQPYN AEDFDDIFSS IFGQHGRHSH HRHAARGHDI
     EIEVAVFLEE TLEEHQRTIS YSVPVYNAFG LVEREIPKTL NVKIPAGVSN GQRIRLKGQG
     TPGENGGPNG DLWLVIHIAP HPLFDIVNQD LEVVLPLAPW EAALGAKVSV PTLKERILLT
     IPPGSQAGQR LRIKGKGLAS KKHTGDLYAI IKIVMPPKPD EKTAALWQQL ADAQSSFDPR
     QQWGKA