ID   YOMI_BACSU              Reviewed;        2285 AA.
AC   O31976;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=SPbeta prophage-derived uncharacterized transglycosylase YomI;
DE            EC=4.2.2.-;
GN   Name=yomI; OrderedLocusNames=BSU21350;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [2]
RP   SEQUENCE REVISION TO 1916-1917.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
CC   -!- SIMILARITY: Belongs to the transglycosylase Slt family. {ECO:0000305}.
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DR   EMBL; AL009126; CAB14053.2; -; Genomic_DNA.
DR   RefSeq; NP_390018.2; NC_000964.3.
DR   RefSeq; WP_004398858.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O31976; -.
DR   SMR; O31976; -.
DR   IntAct; O31976; 1.
DR   STRING; 224308.BSU21350; -.
DR   CAZy; GH23; Glycoside Hydrolase Family 23.
DR   MEROPS; M23.A04; -.
DR   PaxDb; O31976; -.
DR   PRIDE; O31976; -.
DR   EnsemblBacteria; CAB14053; CAB14053; BSU_21350.
DR   GeneID; 939138; -.
DR   KEGG; bsu:BSU21350; -.
DR   PATRIC; fig|224308.179.peg.2331; -.
DR   eggNOG; COG0739; Bacteria.
DR   eggNOG; COG0741; Bacteria.
DR   eggNOG; COG1196; Bacteria.
DR   OMA; HYTIEED; -.
DR   BioCyc; BSUB:BSU21350-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008933; F:lytic transglycosylase activity; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR   GO; GO:0000270; P:peptidoglycan metabolic process; IEA:InterPro.
DR   Gene3D; 2.70.70.10; -; 1.
DR   InterPro; IPR011055; Dup_hybrid_motif.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR016047; Peptidase_M23.
DR   InterPro; IPR010090; Phage_tape_meas.
DR   InterPro; IPR000189; Transglyc_AS.
DR   InterPro; IPR008258; Transglycosylase_SLT_dom_1.
DR   Pfam; PF01551; Peptidase_M23; 1.
DR   Pfam; PF10145; PhageMin_Tail; 1.
DR   Pfam; PF01464; SLT; 1.
DR   SUPFAM; SSF51261; SSF51261; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
DR   TIGRFAMs; TIGR01760; tape_meas_TP901; 1.
DR   PROSITE; PS00922; TRANSGLYCOSYLASE; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Lyase; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..2285
FT                   /note="SPbeta prophage-derived uncharacterized
FT                   transglycosylase YomI"
FT                   /id="PRO_0000360831"
FT   REPEAT          37..71
FT                   /note="TPR 1"
FT   REPEAT          231..264
FT                   /note="TPR 2"
FT   REPEAT          519..553
FT                   /note="TPR 3"
FT   REPEAT          609..642
FT                   /note="TPR 4"
FT   REPEAT          837..871
FT                   /note="TPR 5"
FT   REPEAT          1079..1112
FT                   /note="TPR 6"
FT   REPEAT          1317..1350
FT                   /note="TPR 7"
FT   REPEAT          1484..1517
FT                   /note="TPR 8"
FT   REPEAT          1719..1752
FT                   /note="TPR 9"
FT   REPEAT          1851..1884
FT                   /note="TPR 10"
FT   REGION          138..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1426..1660
FT                   /note="Transglycosylase"
FT   COILED          985..1030
FT                   /evidence="ECO:0000255"
FT   COILED          1219..1262
FT                   /evidence="ECO:0000255"
FT   COILED          1790..1837
FT                   /evidence="ECO:0000255"
FT   COILED          1963..2074
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        164..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1447
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10071"
SQ   SEQUENCE   2285 AA;  252295 MW;  A8895DE671F8D03F CRC64;
     MSQNLKIILT PQADTSSKTV EQLNQQIKSL EKKLNSLKLN TNIDSTTLKA LQEFSSAIDT
     YQKNLKSYNQ TVKETSTVIK NADGSVEKLT QQYKKNGEIL QRETKIINNR NTALKQETQE
     VNKLTQATEK LGQVQKKTVQ RNLQGQPTKV VQKNRHGFDD IVYTTDPKTN STSSKTTTNY
     DQQRRAIEQL KQDLEKLRQQ GIVTDTTISS LGRKINTAQS AQQIEALQNR IRMLDDKSAA
     VAKNNELKKT IELYQRQAQV NVQNLNTRYG SSMGSSNRQA VQDYLNAVNS LNVSTGSNNI
     RSQIQSLNMQ FRELASNAQT AANQASSFGA ELTQTFKSMS TYLISGSLFY GAISGLKEMV
     SQAIEIDTLM TNIRRVMNEP DYKYNELLQE SIDLGDTLSN KITDILQMTG DFGRMGFDES
     ELSTLTKTAQ VLQNVSDLTP DDTVNTLTAA MLNFNIAAND SISIADKLNE VDNNYAVTTL
     DLANSIRKAG STASTFGVEL NDLIGYTTAI ASTTRESGNI VGNSLKTIFA RIGNNQSSIK
     ALEQIGISVK TAGGEAKSAS DLISEVAGKW DTLSDAQKQN TSIGVAGIYQ LSRFNAMMNN
     FSIAQNAAKT AANSTGSAWS EQQKYADSLQ ARVNKLQNNF TEFAIAASDA FISDGLIEFT
     QAAGSLLNAS TGVIKSVGFL PPLLAAVSTA TLLLSKNTRT LASSLILGTR AMGQETLATA
     GLEAGMTRAA VASRVLKTAL RGLLVSTLVG GAFAALGWAL ESLISSFAEA KKAKDDFEQS
     QQTNVEAITT NKDSTDKLIQ QYKELQKVKE SRSLTSDEEQ EYLQVTQQLA QTFPALVKGY
     DSQGNAILKT NKELEKAIEN TKEYLALKKQ ETRDSAKKTF EDASKEIKKS KDELKQYKQI
     ADYNDKGRPK WDLIADDDDY KVAADKAKQS MLKAQSDIES GNAKVKDSVL SIANAYSSID
     ISNTLKTSIS DVVNKLNLKD DLDPEELEKF SSSLGKLQEK MQKALDSGDE KAFDNAKKDL
     QSLLETYSKS DSSIDVFKMS FDKAQKNIKD GDKSLSSVKS EVGDLGETLA EAGNEAEDFG
     KKLKEALDAN SVDDIKAAIK EMSDAMQFDS VQDVLNGDIF NNTKDQVAPL NDLLEKMAEG
     KSISANEANT LIQKDKELAQ AISIENGVVK INRDEVIKQR KVKLDAYNDM VTYSNKLMKT
     EVNNAIKTLN ADTLRIDSLK KLRKERKLDM SEAELSDLEV KSINNVADAK KELKKLEEKM
     LQPGGYSNSQ IEAMQSVKSA LESYISASEE ATSTQEMNKQ ALVEAGTSLE NWTDQQEKAN
     EETKTSMYVV DKYKEALEKV NAEIDKYNKQ VNDYPKYSQK YRDAIKKEIK ALQQKKKLMQ
     EQAKLLKDQI KSGNITQYGI VTSTTSSGGT PSSTGGSYSG KYSSYINSAA SKYNVDPALI
     AAVIQQESGF NAKARSGVGA MGLMQLMPAT AKSLGVNNAY DPYQNVMGGT KYLAQQLEKF
     GGNVEKALAA YNAGPGNVIK YGGIPPFKET QNYVKKIMAN YSKSLSSATS SIASYYTNNS
     AFRVSSKYGQ QESGLRSSPH KGTDFAAKAG TAIKSLQSGK VQIAGYSKTA GNWVVIKQDD
     GTVAKYMHML NTPSVKAGQS VKAGQTIGKV GSTGNSTGNH LHLQIEQNGK TIDPEKYMQG
     IGTSISDASQ AEAERQQGIA QAKSDLLSLQ GDISSVNDQI QELQYELVQS KLDEFDKRIG
     DFDVRIAKDE SMANRYTSDS KEFRKYTSDQ KKAVAEQAKI QQQKVNWIQK EIKTNKALNS
     AQRAQLQEEL KQAKLDLISV QDQVRELQKQ LVQSKVDETL KSIEKSSSKT QGKIKDVDNK
     ISMTEEDEDK VKYYSKQIKL IQQQQKEAKK YIKQLEEQKK AAKGFPDIQE QITEEIENWK
     DKQKDFNLEL YNTKKSIKDI YKSLADEVVS IYKEMYEKMR DIELEAHQKA TQDLIDEIDK
     TDDEAKFQKE LKERQDSIQK LTDQINQYSL DDSEFGKSKV KELTEQLQKE QLDLDDFLKD
     RESNKRKEAL QDQLEKDEES INNKYDNLVN DERAFKKLED KIMNGKITDI AKQLNEFSKF
     INTNMESIGK SISNNLIDKL KEASNALNTA VKGNTTGKKV SSFASGGYTG TGLGAGKLAF
     LHDKELILNK TDTANILDTV KAVRETAVDD SPKWGQGVKL ADLIKKGITS IPSLVPNVNQ
     SMLTNSLIPN LKKIEIPSKT IASSGDKTIN LTNTFHIDKL IGGESGARSM FESIKNEVVK
     LNGSM