YOOH_SCHPO
ID YOOH_SCHPO Reviewed; 625 AA.
AC O94300;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Putative xanthine/uracil permease C887.17;
GN ORFNames=SPBC887.17;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. Azg-like subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329671; CAA21902.1; -; Genomic_DNA.
DR PIR; T40742; T40742.
DR RefSeq; NP_596491.1; NM_001022411.2.
DR AlphaFoldDB; O94300; -.
DR BioGRID; 277755; 29.
DR STRING; 4896.SPBC887.17.1; -.
DR iPTMnet; O94300; -.
DR MaxQB; O94300; -.
DR PaxDb; O94300; -.
DR PRIDE; O94300; -.
DR EnsemblFungi; SPBC887.17.1; SPBC887.17.1:pep; SPBC887.17.
DR GeneID; 2541241; -.
DR KEGG; spo:SPBC887.17; -.
DR PomBase; SPBC887.17; -.
DR VEuPathDB; FungiDB:SPBC887.17; -.
DR eggNOG; ENOG502QQ5E; Eukaryota.
DR HOGENOM; CLU_024508_3_2_1; -.
DR InParanoid; O94300; -.
DR OMA; RKGSYFF; -.
DR PhylomeDB; O94300; -.
DR PRO; PR:O94300; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:PomBase.
DR GO; GO:0015207; F:adenine transmembrane transporter activity; ISS:PomBase.
DR GO; GO:0015208; F:guanine transmembrane transporter activity; ISS:PomBase.
DR GO; GO:0005345; F:purine nucleobase transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0098702; P:adenine import across plasma membrane; IC:PomBase.
DR GO; GO:0015853; P:adenine transport; IBA:GO_Central.
DR GO; GO:0098710; P:guanine import across plasma membrane; IC:PomBase.
DR GO; GO:0015854; P:guanine transport; IBA:GO_Central.
DR InterPro; IPR045018; Azg-like.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR43337; PTHR43337; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..625
FT /note="Putative xanthine/uracil permease C887.17"
FT /id="PRO_0000316575"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 595..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 625 AA; 68563 MW; 88686802B6737DB1 CRC64;
MSITQKVRNW VEEFDVIVAR SAFGRWFRLE GCGHPRERKG SRFSLEISAG LTTFFAMAYI
LAVNATILVD TGGTCECTEA NRDDCDKLDD YVLCKEDFHR DLVTATAAIS ALASFCMGLF
ANMPVGMAPG MGLNAYFAYQ VVGYNGTGRV SYREALLAVF VEGFIFTGLT VIGLRQWLAR
VIPASLKFAT GAGIGLYLTI IGLSPSAGLG VIGHSSSDIV ALGGCPPEYL NADYSCNGHQ
LQSGRMWVGI FCGGVLTAIL MMYKFKGAVL AGIALVTITS WPRRSLVTMF PHTLTGDYNF
DFFKKVVSFR KINRILVAQQ WNVTGGQFAI ALITFLYVDI MDMTGTLYSM ANYAGLVDPR
TQDFEGSAVA YIVDALSISI GSLFGCSPVT AFIESGSGIS AGGRTGILGM VVGICFFISL
FFAPIFSSIP VWATGSTLVL VGSMMMKSTT LINWSYLGDS IPAFITIALM PFTYSIAYGL
IAGIICYALL NSIIYAIDKM SRGRLVPADY NQKEAWTWRV EGGLLPQWVR RLFKGNRRFW
EDPDDRKAMD NATLEMATSR SYSEDGKNEK TTHEDVTMKE TSLKKMDDER ISVDEAVGES
ESFSNRQQDF RTPYAGIDMD TDDRI
