ID   YOP1_ASPFU              Reviewed;         169 AA.
AC   Q4WTW3;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Protein yop1;
GN   Name=yop1; ORFNames=AFUA_5G06320;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Required to generate and maintain the structure of the
CC       tubular endoplasmic reticulum network and the vacuole. Induces high
CC       curvature in membranes and causes membrane tubule formation. Involved
CC       in membrane/vesicle trafficking. {ECO:0000250|UniProtKB:Q12402}.
CC   -!- SUBUNIT: Oligomer. {ECO:0000250|UniProtKB:Q12402}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q12402}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q12402}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q12402}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DOMAIN: The short lumenal loops between transmembrane domains 1 and 2
CC       and between transmembrane domains 3 and 4 may impart a wedge-like
CC       configuration, thus deforming membranes.
CC       {ECO:0000250|UniProtKB:Q12402}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR   EMBL; AAHF01000003; EAL91963.1; -; Genomic_DNA.
DR   RefSeq; XP_754001.1; XM_748908.1.
DR   AlphaFoldDB; Q4WTW3; -.
DR   STRING; 746128.CADAFUBP00005272; -.
DR   EnsemblFungi; EAL91963; EAL91963; AFUA_5G06320.
DR   GeneID; 3511329; -.
DR   KEGG; afm:AFUA_5G06320; -.
DR   VEuPathDB; FungiDB:Afu5g06320; -.
DR   eggNOG; KOG1725; Eukaryota.
DR   HOGENOM; CLU_028431_2_1_1; -.
DR   InParanoid; Q4WTW3; -.
DR   OMA; FILVLWM; -.
DR   OrthoDB; 1473891at2759; -.
DR   Proteomes; UP000002530; Chromosome 5.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Golgi apparatus; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..169
FT                   /note="Protein yop1"
FT                   /id="PRO_0000101848"
FT   TOPO_DOM        1..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        36..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        56
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        57..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        77..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        87..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        104..105
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        106..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        125..169
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
SQ   SEQUENCE   169 AA;  19069 MW;  373F70DA47AB939D CRC64;
     MASFQDRAQH TIAQLDKELS KYPVLNNLER QTSVPKVYVI LGLVGIYTFL VFFNIAGEFL
     VNFAGFLIPG YYSLNALFTS GKADDTQWLT YWVVYALLTV VESAINAAYW FPFYYIFKFV
     LILWMSLPQT NGAQVVFHSF LQPVLGRFFT SGSTSANLRA QADAASKSQ