ID   YOP1_CRYNJ              Reviewed;         206 AA.
AC   P0CN16; Q55R79; Q5KEZ1;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=Protein YOP1;
GN   Name=YOP1; OrderedLocusNames=CNF03700;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required to generate and maintain the structure of the
CC       tubular endoplasmic reticulum network and the vacuole. Induces high
CC       curvature in membranes and causes membrane tubule formation. Involved
CC       in membrane/vesicle trafficking. {ECO:0000250|UniProtKB:Q12402}.
CC   -!- SUBUNIT: Oligomer. {ECO:0000250|UniProtKB:Q12402}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q12402}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q12402}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q12402}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DOMAIN: The short lumenal loops between transmembrane domains 1 and 2
CC       and between transmembrane domains 3 and 4 may impart a wedge-like
CC       configuration, thus deforming membranes.
CC       {ECO:0000250|UniProtKB:Q12402}.
CC   -!- SIMILARITY: Belongs to the DP1 family. {ECO:0000305}.
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DR   EMBL; AE017346; AAW44134.1; -; Genomic_DNA.
DR   RefSeq; XP_571441.1; XM_571441.1.
DR   AlphaFoldDB; P0CN16; -.
DR   SMR; P0CN16; -.
DR   STRING; 5207.AAW44134; -.
DR   PaxDb; P0CN16; -.
DR   EnsemblFungi; AAW44134; AAW44134; CNF03700.
DR   GeneID; 3258144; -.
DR   KEGG; cne:CNF03700; -.
DR   VEuPathDB; FungiDB:CNF03700; -.
DR   eggNOG; KOG1725; Eukaryota.
DR   HOGENOM; CLU_028431_2_1_1; -.
DR   InParanoid; P0CN16; -.
DR   OMA; TNDDKQW; -.
DR   OrthoDB; 1473891at2759; -.
DR   Proteomes; UP000002149; Chromosome 6.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; PTHR12300; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Golgi apparatus; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..206
FT                   /note="Protein YOP1"
FT                   /id="PRO_0000101850"
FT   TOPO_DOM        1..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        53..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        73..74
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        96..105
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        106..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        123..126
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TRANSMEM        127..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   TOPO_DOM        146..206
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q12402"
FT   REGION          177..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   206 AA;  23050 MW;  032FF6EC6C1FFB8B CRC64;
     MAAHSEQIKN NFLNNPYAQQ VFNIANGQVS ALDAELNKYP ILRQLEQQTK VPKAYGVIAL
     GFSSVLLIFF NMFGLAQPIS NLIGWALPAY LSILAIESPQ TNDDKQWLTY WVVFGSLNLV
     ESMGLRAVLY WVPMYFVFKT LFTIWLMLPA TRGAEILYFH FLRPMVGNVK SRSQSSFGTS
     DPLAKETGFN PAGTTAPSSF AHEKTL