YOPE_YERPE
ID YOPE_YERPE Reviewed; 219 AA.
AC P31493;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 25-MAY-2022, entry version 149.
DE RecName: Full=Outer membrane virulence protein YopE;
GN Name=yopE; Synonyms=yop25;
GN OrderedLocusNames=YPCD1.06, y5068, y0077, YP_pCD81;
OS Yersinia pestis.
OG Plasmid pCD1, and Plasmid pYV019.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=EV 76; PLASMID=pYV019;
RX PubMed=2307658; DOI=10.1128/jb.172.3.1547-1555.1990;
RA Forsberg A., Wolf-Watz H.;
RT "Genetic analysis of the yopE region of Yersinia spp.: identification of a
RT novel conserved locus, yerA, regulating yopE expression.";
RL J. Bacteriol. 172:1547-1555(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis; PLASMID=pCD1;
RX PubMed=9746557; DOI=10.1128/iai.66.10.4611-4623.1998;
RA Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J.,
RA Blattner F.R.;
RT "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of
RT Yersinia pestis KIM5.";
RL Infect. Immun. 66:4611-4623(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=KIM5 / Biovar Mediaevalis; PLASMID=pCD1;
RX PubMed=9748454; DOI=10.1128/jb.180.19.5192-5202.1998;
RA Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A.,
RA Brubaker R.R., Garcia E.;
RT "Structural organization of virulence-associated plasmids of Yersinia
RT pestis.";
RL J. Bacteriol. 180:5192-5202(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis; PLASMID=pCD1;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis; PLASMID=pCD1;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Essential virulence determinant; cytotoxic effector, involved
CC in resistance to phagocytosis.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC -!- INDUCTION: At 37 degrees Celsius in the absence of calcium.
CC -!- MISCELLANEOUS: N-terminal is important for export, C-terminal is
CC indispensable for virulence.
CC -!- SIMILARITY: Belongs to the YopE family. {ECO:0000305}.
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DR EMBL; M34279; AAA27672.1; -; Genomic_DNA.
DR EMBL; AF074612; AAC69818.1; -; Genomic_DNA.
DR EMBL; AF053946; AAC62587.1; -; Genomic_DNA.
DR EMBL; AL117189; CAB54883.1; -; Genomic_DNA.
DR EMBL; AE017043; AAS58592.1; -; Genomic_DNA.
DR PIR; T43605; T43605.
DR RefSeq; NP_395143.1; NC_003131.1.
DR RefSeq; NP_857762.1; NC_004836.1.
DR RefSeq; NP_857967.1; NC_004839.1.
DR RefSeq; WP_002229754.1; NZ_WUCM01000133.1.
DR PDB; 1HY5; X-ray; 2.25 A; A/B=90-219.
DR PDBsum; 1HY5; -.
DR AlphaFoldDB; P31493; -.
DR BMRB; P31493; -.
DR SMR; P31493; -.
DR IntAct; P31493; 2.
DR MINT; P31493; -.
DR STRING; 214092.5832429; -.
DR DNASU; 1149332; -.
DR EnsemblBacteria; AAS58592; AAS58592; YP_pCD81.
DR GeneID; 66841063; -.
DR KEGG; ype:YPCD1.06; -.
DR KEGG; ypm:YP_pCD81; -.
DR PATRIC; fig|214092.21.peg.8; -.
DR eggNOG; COG5599; Bacteria.
DR HOGENOM; CLU_121002_0_0_6; -.
DR OMA; KSEQYAN; -.
DR EvolutionaryTrace; P31493; -.
DR Proteomes; UP000000815; Plasmid pCD1.
DR Proteomes; UP000001019; Plasmid pCD1.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0050765; P:negative regulation of phagocytosis; IMP:CACAO.
DR CDD; cd00219; ToxGAP; 1.
DR Gene3D; 1.20.120.260; -; 1.
DR InterPro; IPR003537; YopE-like.
DR InterPro; IPR014773; YopE_GAP_dom.
DR InterPro; IPR037168; YopE_GAP_dom_sf.
DR InterPro; IPR015110; YopE_N_dom.
DR Pfam; PF03545; YopE; 1.
DR Pfam; PF09020; YopE_N; 1.
DR PRINTS; PR01372; YERSINIAYOPE.
DR SUPFAM; SSF47233; SSF47233; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Membrane; Plasmid; Reference proteome;
KW Virulence.
FT CHAIN 1..219
FT /note="Outer membrane virulence protein YopE"
FT /id="PRO_0000066366"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 102..121
FT /evidence="ECO:0007829|PDB:1HY5"
FT HELIX 126..136
FT /evidence="ECO:0007829|PDB:1HY5"
FT HELIX 142..156
FT /evidence="ECO:0007829|PDB:1HY5"
FT HELIX 159..170
FT /evidence="ECO:0007829|PDB:1HY5"
FT STRAND 171..173
FT /evidence="ECO:0007829|PDB:1HY5"
FT HELIX 178..182
FT /evidence="ECO:0007829|PDB:1HY5"
FT STRAND 184..186
FT /evidence="ECO:0007829|PDB:1HY5"
FT HELIX 187..192
FT /evidence="ECO:0007829|PDB:1HY5"
FT TURN 193..195
FT /evidence="ECO:0007829|PDB:1HY5"
FT HELIX 199..211
FT /evidence="ECO:0007829|PDB:1HY5"
FT HELIX 213..218
FT /evidence="ECO:0007829|PDB:1HY5"
SQ SEQUENCE 219 AA; 22987 MW; 8E07FF064947B60D CRC64;
MKISSFISTS LPLPTSVSGS SSVGEMSGRS VSQQTSDQYA NNLAGRTESP QGSSLASRII
ERLSSVAHSV IGFIQRMFSE GSHKPVVTPA PTPAQMPSPT SFSDSIKQLA AETLPKYMQQ
LNSLDAEMLQ KNHDQFATGS GPLRGSITQC QGLMQFCGGE LQAEASAILN TPVCGIPFSQ
WGTIGGAASA YVASGVDLTQ AANEIKGLAQ QMQKLLSLM
