ID   YOPN_YERPS              Reviewed;         293 AA.
AC   Q663K1; P16160;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Outer membrane protein YopN;
DE   AltName: Full=LcrE;
DE   AltName: Full=Yop4b;
GN   Name=yopN; Synonyms=lcrE; OrderedLocusNames=pYV0065;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OG   Plasmid pIB1, and Plasmid pYV.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-9.
RC   STRAIN=YPIII / Serotype O:3; PLASMID=pIB1;
RX   PubMed=1857212; DOI=10.1111/j.1365-2958.1991.tb00773.x;
RA   Forsberg A., Viitanen A.-M., Skurnik M., Wolf-Watz H.;
RT   "The surface-located YopN protein is involved in calcium signal
RT   transduction in Yersinia pseudotuberculosis.";
RL   Mol. Microbiol. 5:977-986(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953; PLASMID=pYV;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Plays a major role in regulation of the low-calcium response.
CC       Seems to sense the calcium concentration and to transmit a signal to
CC       shut off yop transcription when the calcium concentration is high.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- SIMILARITY: Belongs to the HrpJ/YopN family. {ECO:0000305}.
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DR   EMBL; X51833; CAA36129.1; -; Genomic_DNA.
DR   EMBL; BX936399; CAF25408.1; -; Genomic_DNA.
DR   PIR; S15320; S15320.
DR   RefSeq; WP_011191384.1; NZ_CP009711.1.
DR   AlphaFoldDB; Q663K1; -.
DR   SMR; Q663K1; -.
DR   EnsemblBacteria; CAF25408; CAF25408; pYV0065.
DR   GeneID; 66841109; -.
DR   KEGG; ypo:BZ17_4268; -.
DR   KEGG; yps:pYV0065; -.
DR   PATRIC; fig|273123.14.peg.4504; -.
DR   OMA; GINAIWS; -.
DR   PHI-base; PHI:8619; -.
DR   Proteomes; UP000001011; Plasmid pYV.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009986; C:cell surface; IEA:InterPro.
DR   GO; GO:0050709; P:negative regulation of protein secretion; IEA:InterPro.
DR   GO; GO:0030254; P:protein secretion by the type III secretion system; IEA:InterPro.
DR   InterPro; IPR010812; HrpJ-like.
DR   InterPro; IPR013401; T3SS_LcrE.
DR   Pfam; PF07201; HrpJ; 1.
DR   TIGRFAMs; TIGR02568; LcrE; 1.
PE   1: Evidence at protein level;
KW   Calcium; Cell outer membrane; Direct protein sequencing; Membrane; Plasmid;
KW   Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:1857212"
FT   CHAIN           2..293
FT                   /note="Outer membrane protein YopN"
FT                   /id="PRO_0000066372"
FT   CONFLICT        260
FT                   /note="N -> S (in Ref. 1; CAA36129)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   293 AA;  32697 MW;  89BFCE01C6B4382C CRC64;
     MTTLHNLSYG NTPLHNERPE IASSQIVNQT LGQFRGESVQ IVSGTLQSIA DMAEEVTFVF
     SERKELSLDK RKLSDSQARV SDVEEQVNQY LSKVPELEQK QNVSELLSLL SNSPNISLSQ
     LKAYLEGKSE EPSEQFKMLC GLRDALKGRP ELAHLSHLVE QALVSMAEEQ GETIVLGARI
     TPEAYRESQS GVNPLQPLRD TYRDAVMGYQ GIYAIWSDLQ KRFPNGDIDS VILFLQKALS
     ADLQSQQSGS GREKLGIVIN DLQKLKEFGS VSDQVKGFWQ FFSEGKTNGV RPF