ID   YOPP_BACSU              Reviewed;         358 AA.
AC   O34336;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=SPbeta prophage-derived probable integrase/recombinase YopP;
GN   Name=yopP; OrderedLocusNames=BSU20810;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [2]
RP   DISRUPTION PHENOTYPE, AND FUNCTION.
RC   STRAIN=168;
RX   PubMed=11208805; DOI=10.1128/jb.183.3.1058-1068.2001;
RA   Sciochetti S.A., Piggot P.J., Blakely G.W.;
RT   "Identification and characterization of the dif site from Bacillus
RT   subtilis.";
RL   J. Bacteriol. 183:1058-1068(2001).
CC   -!- FUNCTION: Probable recombinase that does not seem to have a role in
CC       chromosome dimer resolution per se but rather may have some
CC       facilitative role during chromosome partitioning in general.
CC       {ECO:0000269|PubMed:11208805}.
CC   -!- DISRUPTION PHENOTYPE: Little effect on the percentage of cells with
CC       partition defects and no change in sporulation frequency. However, yopP
CC       disruption strongly increases the extent of the partitioning defects
CC       seen in codV mutant strains (by about two-fold) and, to a lesser
CC       extent, those seen in ripX and dif mutant strains.
CC       {ECO:0000269|PubMed:11208805}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family. {ECO:0000305}.
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DR   EMBL; AL009126; CAB13973.1; -; Genomic_DNA.
DR   RefSeq; NP_389963.1; NC_000964.3.
DR   RefSeq; WP_004399272.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O34336; -.
DR   SMR; O34336; -.
DR   STRING; 224308.BSU20810; -.
DR   PaxDb; O34336; -.
DR   EnsemblBacteria; CAB13973; CAB13973; BSU_20810.
DR   GeneID; 936482; -.
DR   KEGG; bsu:BSU20810; -.
DR   PATRIC; fig|224308.179.peg.2271; -.
DR   eggNOG; COG0582; Bacteria.
DR   OMA; INERQKP; -.
DR   BioCyc; BSUB:BSU20810-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004107; Integrase_SAM-like_N.
DR   Pfam; PF02899; Phage_int_SAM_1; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Chromosome partition; DNA integration;
KW   DNA recombination; DNA-binding; Reference proteome;
KW   Viral genome integration; Virus entry into host cell.
FT   CHAIN           1..358
FT                   /note="SPbeta prophage-derived probable
FT                   integrase/recombinase YopP"
FT                   /id="PRO_0000384390"
FT   DOMAIN          23..114
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01248"
FT   DOMAIN          137..319
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        178
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        206
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        268
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        295
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        304
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   358 AA;  41596 MW;  7011BF29697AF684 CRC64;
     MQNKIKQLKN YAVYDDIEGF LINKDIRSSS GNSNYMMPSS TRRVSNTRKN YEGDIKQFFS
     VIKGKDVKSL VPDDLVVSKS ELSNYVKYLQ EKGLVNNSIN RKMTSLKMLY TYLEHDYKDY
     IDLSVFNTVE RLKTVTKNWD KTTQTEAERI AQDMYINERQ KPLMKKLFVK FAIRTSFRVS
     AILRVRWKDI QLDESTGHYI VTVIDKGSQV VSTGINQVFY EELLQLKEED DSETELVFQG
     LSEQSLRHSL KRSKKRLGIP PERELVLHSF KGVGIDYVYE NSGHDLLAAK EQGNHKNTLT
     TERYMSRKIN IANSAGVTMD EKIDLNPLYE ATQEDFISFF ENADLVTLKK FIKHVNER