ID   YORL_BACSU              Reviewed;        1305 AA.
AC   O31902;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Probable DNA polymerase YorL;
DE            EC=2.7.7.7;
GN   Name=yorL; OrderedLocusNames=BSU20340;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: Probable DNA polymerase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. {ECO:0000305}.
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DR   EMBL; AL009126; CAB13926.1; -; Genomic_DNA.
DR   RefSeq; NP_389916.1; NC_000964.3.
DR   RefSeq; WP_009967475.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O31902; -.
DR   SMR; O31902; -.
DR   STRING; 224308.BSU20340; -.
DR   PaxDb; O31902; -.
DR   PRIDE; O31902; -.
DR   EnsemblBacteria; CAB13926; CAB13926; BSU_20340.
DR   GeneID; 939437; -.
DR   KEGG; bsu:BSU20340; -.
DR   PATRIC; fig|224308.179.peg.2224; -.
DR   eggNOG; COG0587; Bacteria.
DR   OMA; HYGEDRV; -.
DR   PhylomeDB; O31902; -.
DR   BioCyc; BSUB:BSU20340-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.1600; -; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
KW   DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..1305
FT                   /note="Probable DNA polymerase YorL"
FT                   /id="PRO_0000360650"
SQ   SEQUENCE   1305 AA;  150538 MW;  B4E4E694C807D1C0 CRC64;
     MIGCHCHTDR SNIRLLDSTN SVKELLKTAV KMEYKGLAIT DHEVLSAHLD AIRTVREMKK
     KGDMPEDFKL ILGNEAYLVD SLEEVRDNYK SGVTKFPHFL MLAMDPKGHE QLRILSSQAW
     ENSFYTGTME RVPTVKKDVE ELLSKDPGHI IATTACLGSE VNIHLLKIKA FEETGDSQSI
     KQHKLKIHEF ITWCIEVFGK DKFFIELQPA LSEEQIYCNK KLIDIANGYD LQMIVTTDAH
     YLRPEDRAIH QAFLNAKDGE REVDSFYEAC FVQNVDEIHE RMDYIDKEVI DQAIKNTMLI
     GEMIEDYTIE HEPIIPKMEL PNFKLRHLFK PAYDQYEYIK KMSESADEQD RYLLKLIEDG
     FEEKLKTSEL TREAFHKILN RINVELGELW EISQKLNQSM SSYYITVREI INIIWDDECG
     GDSLVGAARG SAAGYLVNYL LDNTQINPMQ YDLPHWRHIH KSRPDLPDID IDTEGSKRQK
     ILKALRERFG DKRVLQIATF GTEGSKSALQ TACRGLGIDN DISQYLSGMI PFERGSNWPL
     KHCFYGDKET GRKPIKEFIR EVEQYPNLKE TALKIEGLTN KRSSHAAGVI IFNDEYTKSN
     AMMKTPKGAY ITQFNMGDSE AMGSVKFDLL TIEALDKIRV TLDQLIENNE IEWQGSLKET
     YNKYIHPDVI EYEDDKLWEM AGNGEIMDLF QFSTEVGHQS VVKVKPKNLL EAAVTNSLMR
     LMSDGEEQPV DTYVKYKNNL NKWYEEMTRY GLSEKEIRVM ERHLKDIYGV ADTQEVVMQM
     VMDKDIANFD IKESNYLRKS IAKKKEDVLK EVEELFFKKG KEIGTSDNLL NYVWNVQFKR
     QFGYSFSLLH TLAYSIIALQ ELNLNYRYNP LYWNTACLTV NSGGIDTEDT KDNKKTAATN
     YGKVASAIGN IRQRGIKIDL PDINKADFGF RTDINNNSIL FGLKGMNGIG DDVIHHIVLN
     RPYSDFNDFI ERMFKSGIIK KGQVIQLIKG GCFDSFGNRQ EIMKAFISLI SEPKSKLTLS
     NLKMLIENNI VPSEFAQEVR FFRFKDYISK KVYKTLKSPK DKLFLLDDVS ASFYNQHFSE
     DSVVDMLNGQ LVISEKAFKK EYDNKMSNIK SWITTEEPLK KLNDCLLIKE WEKYADGSLG
     KWEMDSLSYY YNDHELSGVN FAKYDIADFY KLPAEPVKGK PYQWRGKTLY EYETTRIIGT
     VLDRDKNKHA ITLLTPTGVV TVKQWSGSFS HYNKQISRSI GGGKKEVIEK SWYTRGTLLM
     FTGFRRGNNF IPKVYKDSIY NHTVCRIDFV DNEGSMSLTT KRAEI