YORS_SCHPO
ID YORS_SCHPO Reviewed; 215 AA.
AC O94276;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Meiotic chromosome segregation protein P8B7.28c;
GN ORFNames=SPBP8B7.28c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=16169489; DOI=10.1016/j.cub.2005.07.059;
RA Gregan J., Rabitsch P.K., Sakem B., Csutak O., Latypov V., Lehmann E.,
RA Kohli J., Nasmyth K.;
RT "Novel genes required for meiotic chromosome segregation are identified by
RT a high-throughput knockout screen in fission yeast.";
RL Curr. Biol. 15:1663-1669(2005).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for meiotic chromosome segregation.
CC {ECO:0000269|PubMed:16169489}.
CC -!- INTERACTION:
CC O94276; O74957: ago1; NbExp=2; IntAct=EBI-2651917, EBI-422882;
CC O94276; O60016: clr4; NbExp=2; IntAct=EBI-2651917, EBI-354657;
CC O94276; O74910: raf1; NbExp=2; IntAct=EBI-2651917, EBI-904913;
CC O94276; O74560: raf2; NbExp=3; IntAct=EBI-2651917, EBI-904886;
CC O94276; Q10426: rik1; NbExp=3; IntAct=EBI-2651917, EBI-1111936;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329671; CAA21813.1; -; Genomic_DNA.
DR PIR; T40822; T40822.
DR RefSeq; NP_596535.1; NM_001022456.2.
DR PDB; 2LUY; NMR; -; A=32-126.
DR PDBsum; 2LUY; -.
DR AlphaFoldDB; O94276; -.
DR BMRB; O94276; -.
DR SMR; O94276; -.
DR BioGRID; 277883; 35.
DR IntAct; O94276; 14.
DR STRING; 4896.SPBP8B7.28c.1; -.
DR iPTMnet; O94276; -.
DR PaxDb; O94276; -.
DR PRIDE; O94276; -.
DR EnsemblFungi; SPBP8B7.28c.1; SPBP8B7.28c.1:pep; SPBP8B7.28c.
DR GeneID; 2541372; -.
DR KEGG; spo:SPBP8B7.28c; -.
DR PomBase; SPBP8B7.28c; -.
DR VEuPathDB; FungiDB:SPBP8B7.28c; -.
DR HOGENOM; CLU_1283928_0_0_1; -.
DR PRO; PR:O94276; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005721; C:pericentric heterochromatin; IDA:PomBase.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IPI:PomBase.
DR GO; GO:0031048; P:heterochromatin assembly by small RNA; IMP:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEP:PomBase.
DR GO; GO:0031508; P:pericentric heterochromatin assembly; IMP:PomBase.
DR GO; GO:0030466; P:silent mating-type cassette heterochromatin assembly; IMP:PomBase.
DR GO; GO:0031509; P:subtelomeric heterochromatin assembly; IMP:PomBase.
DR Gene3D; 3.30.60.210; -; 2.
DR InterPro; IPR024630; Stc1.
DR InterPro; IPR043069; Stc1_sf.
DR Pfam; PF12898; Stc1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..215
FT /note="Meiotic chromosome segregation protein P8B7.28c"
FT /id="PRO_0000352818"
FT REGION 159..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 35..37
FT /evidence="ECO:0007829|PDB:2LUY"
FT STRAND 39..41
FT /evidence="ECO:0007829|PDB:2LUY"
FT STRAND 43..45
FT /evidence="ECO:0007829|PDB:2LUY"
FT STRAND 48..50
FT /evidence="ECO:0007829|PDB:2LUY"
FT TURN 51..53
FT /evidence="ECO:0007829|PDB:2LUY"
FT HELIX 56..60
FT /evidence="ECO:0007829|PDB:2LUY"
FT STRAND 63..66
FT /evidence="ECO:0007829|PDB:2LUY"
FT STRAND 69..72
FT /evidence="ECO:0007829|PDB:2LUY"
FT TURN 81..83
FT /evidence="ECO:0007829|PDB:2LUY"
FT STRAND 90..92
FT /evidence="ECO:0007829|PDB:2LUY"
FT STRAND 94..96
FT /evidence="ECO:0007829|PDB:2LUY"
FT STRAND 99..102
FT /evidence="ECO:0007829|PDB:2LUY"
FT HELIX 107..111
FT /evidence="ECO:0007829|PDB:2LUY"
FT STRAND 112..114
FT /evidence="ECO:0007829|PDB:2LUY"
FT HELIX 118..121
FT /evidence="ECO:0007829|PDB:2LUY"
SQ SEQUENCE 215 AA; 25075 MW; 783938BC76B88452 CRC64;
MDFKSRKYKI KKHPKDCKLH AKKYRGTLNS KGKNDNDCLI MCMRCRKVKG IDSYSKTQWS
KTFTFVRGRT VSVSDPKVIC RTCQPKQHDS IWCTACQQTK GINEFSKAQR HVLDPRCQIC
VHSQRNDGDD NLESDKFVDP FIGDDSDLDD DIYIHDKQTI NSEYADDVSD NTDEERTESK
GQQESNSAEE YDDDDSDEDR MEEIFQQFKK EKQIV
